The Organ Protection of Astragalus in Subjects With Metabolic Syndrome

NCT ID: NCT01847807

Last Updated: 2015-10-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

210 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-01-31

Brief Summary

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Metabolic syndrome have the damages on tissues and organs in heart、kindey and vessels. In this study, prospective randomized, controlled, parallel designed ,different doses of Astragalus Mongolia, Gansu Longxi produce treat on the MS patients, and then use real-time quantitative PCR and Western Blotting to detect the index of oxidative stress 、angiotensin-converting enzyme 2 mRNA expression and proteins.

Detailed Description

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Conditions

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Metabolic Syndrome

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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High-dose Astragalus group

treatment with 10 gram astragalus

Group Type ACTIVE_COMPARATOR

high dose astagalus

Intervention Type DRUG

Low-dose Astragalus group

treatment with 5 gram astragalus

Group Type ACTIVE_COMPARATOR

low dose Astragalus

Intervention Type DRUG

MS control

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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low dose Astragalus

Intervention Type DRUG

high dose astagalus

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. age 18 years or older, meet the diagnostic criteria of MS
2. non-allergic with the astragalus
3. agree to conduct clinical trials and those who signed the informed consent

Exclusion Criteria

1. patients with resistant hypertension
2. renal disease requiring dialysis
3. heart failure NYHA ⅢorⅣ;
4. complications of diabetes
5. arteritis
6. cancer
7. thyroid disease
8. unstable coronary heart disease
9. peripheral vascular disease
10. acute cerebral vascular disease11.pregnancy、 planned pregnancy
11. patients with anti-oxidants
12. acute infection
13. other organic dysfunction, such as the liver, respiratory system, blood system, and other rheumatic diseases.
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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LanZhou University

OTHER

Sponsor Role lead

Responsible Party

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Jing Yu

cheif of cardiology

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Lanzhou University Second Hospital

Lanzhou, Gansu, China

Site Status

Countries

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China

Other Identifiers

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MS2304

Identifier Type: -

Identifier Source: org_study_id

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