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The Effects of Dietary Fiber in CKD: A Systematic Review and Meta-analysis

NCT ID: NCT01844882

Last Updated: 2014-11-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-01-31

Study Completion Date

2013-08-31

Brief Summary

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Chronic kidney disease (CKD) is a debilitating condition in which there is a gradual decline of renal function associated with increased overall mortality. Most dietary guidelines for CKD focus on limiting protein intake (nitrogen) and high phosphorus-containing foods. However, increasing dietary fiber has been proposed to increase fecal nitrogen excretion which may ameliorate the progress of CKD. We therefore plan to conduct a systematic review and meta-analysis on clinical trials to assess the effect of fiber on urea and creatinine as classical markers of a state of uremia in individuals with CKD. We hypothesize that increasing fiber intakes will improve urea and creatinine levels in individuals with CKD.

Detailed Description

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Conditions

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Chronic Kidney Disease

Study Design

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Study Time Perspective

RETROSPECTIVE

Study Groups

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Chronic Kidney Disease

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Dietary trials in humans
* Randomized treatment allocation
* Suitable control (low fiber)
* viable endpoint data

Exclusion Criteria

* Non-human studies
* Nonrandomized treatment allocation
* Lack of a suitable control (high protein)
* no viable endpoint data
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Unity Health Toronto

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

References

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Chiavaroli L, Mirrahimi A, Sievenpiper JL, Jenkins DJ, Darling PB. Dietary fiber effects in chronic kidney disease: a systematic review and meta-analysis of controlled feeding trials. Eur J Clin Nutr. 2015 Jul;69(7):761-8. doi: 10.1038/ejcn.2014.237. Epub 2014 Nov 12.

Reference Type DERIVED
PMID: 25387901 (View on PubMed)

Other Identifiers

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SMH-CKD-2013

Identifier Type: -

Identifier Source: org_study_id