Abu Dhabi Diabetes and Obesity Study

NCT ID: NCT01843959

Last Updated: 2021-10-13

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 2130 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2013-03-31
• Study Completion Date: 2017-04-30

Brief Summary

A cross-sectional study investigating the aetiology, mechanisms and associated complications contributing to obesity and diabetes within the UAE population. The study will be carried out in two main sample populations; children and adults, and characterized by the occurrence of obesity and diabetes. The main samples will then be divided into a subgroup for metabolomic analysis. Patients will be recruited from the Imperial College London Diabetes Centre. The study is aimed at elucidating the various factors that have an impact or may influence obesity and diabetes in the Emirati population.

Detailed Description

Obesity and Type 2 diabetes (T2DM) have been regarded as global epidemics in developed countries and more recently in developing nations. Obesity (a T2DM risk factor) and T2DM present significant health risks as individual diseases and substantial risks in individuals with both complications (Deepa Nath, 2006). The UAE and USA have a similar prevalence of obesity, 36% and 35.7% respectively. Interestingly, the percentage of the population with T2DM between the two groups differs significantly, 25% and 8.7% respectively. The rate of T2DM in the Emirati population is 2.9 fold higher than in the US. This suggests an altered inter relationship between obesity and T2DM. One hypothesis that could explain such a variation is differences in body metabolism and central adiposity between the two populations. This will be assessed by measuring cardiometabolic risk factors, central adiposity and metabolomics. Analysis of the metabolomic profiles may help define the risk factors associated with diabetes and differences in metabolic activity between various ethnicities.

Another area of ample interest is the advanced glycation end-products (AGEs) metabolic pathways (Pietropaoli D, 2012). AGEs are formed at an increased rate in diabetes and have a number of detrimental effects such as retinopathy, nephropathy and atherosclerosis (Melpomeni Peppa, 2003). As such, determining the core mechanisms that result in metabolic and cardiovascular dysfunction will aid in identifying and developing therapeutic targets, which may in turn alleviate the deleterious effects of respective disorders such as diabetes.

The aetiology of diabetes is complex. However, adenovirus 36 has been shown to play a significant role in obesity and diabetes. As such, analysis of ADV-36 occurrence within the Emirati population may provide insight into a novel obesity and diabetes risk factor and could further clarify the relationship between obesity and T2DM.

This study may provide evidence that clarifies how obesity can result in T2DM, and why this occurrence is more predominant in the Emirati population. In addition, the assessment of AGEs within the population, ranging from people with diabetes and obesity to healthy individual, may provide insight into potential therapeutic targets, thereby improving overall heath in the population. Finally, the data may improve our knowledge of new risk factors such as ADV-36 and their subsequent effects on diabetes.

Conditions

Obesity; Diabetes

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Emirati Population

The individuals enrolled in this study will be divided into children (5-16 years of age) and adults (above 18). The groups will be further divided into BMI categories and glucose tolerance groups.

• Group 1: Underweight (adjusted BMI <10th percentile) and no diabetes

• Group 2:

Normal weight (adjusted BMI 10th to 84.9th percentile) and no diabetes

• Group 3:

Overweight or obese children (adjusted BMI >= 85th percentile) and no diabetes

• Group 4:

Normal weight (adjusted BMI 10th to 84.9th percentile) and T1DM

• Group 5:

Overweight or obese children (adjusted BMI ≥ 85th percentile) and T1DM

• Group 6:

Normal weight (adjusted BMI 10th to 84.9th percentile) and T2DM

• Group 7:

Overweight or obese children (adjusted BMI ≥ 85th percentile) and T2DM

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• All patients are eligible to participate in the study

Exclusion Criteria

• Under 5 years of age

• Minimum Eligible Age: 5 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Imperial College London Diabetes Centre

OTHER

Sponsor Role: lead

Responsible Party

Dr Nader Lessan, MD

Consultant Endocrinologist

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Imperial College London Diabetes Centre

Abu Dhabi, , United Arab Emirates

Countries

United Arab Emirates

References

Almgren M, Atkinson R, He J, Hilding A, Hagman E, Wolk A, Thorell A, Marcus C, Naslund E, Ostenson CG, Schalling M, Lavebratt C. Adenovirus-36 is associated with obesity in children and adults in Sweden as determined by rapid ELISA. PLoS One. 2012;7(7):e41652. doi: 10.1371/journal.pone.0041652. Epub 2012 Jul 27.

Reference Type: BACKGROUND

PMID: 22848557 (View on PubMed)

Atkinson RL. Adenovirus-36 and obesity. Pediatr Obes. 2012 Apr;7(2):e18-9. doi: 10.1111/j.2047-6310.2011.00043.x. No abstract available.

Reference Type: BACKGROUND

PMID: 22434760 (View on PubMed)

Other Identifiers

IREC008

Identifier Type: -

Identifier Source: org_study_id