Study to Evaluate the Pharmacokinetics and Safety of GSK2336805 in Subjects With Hepatic Impairment and Healthy Matched Control Subjects

NCT ID: NCT01827657

Last Updated: 2017-06-14

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 31 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-05-28
• Study Completion Date: 2014-03-20

Brief Summary

This is a single-dose, open-label, two part, parallel group study. This study is being conducted to determine the pharmacokinetics, safety and tolerability of GSK2336805 in subjects with varying degrees of hepatic impairment. Part 1 of the study will enroll subjects with mild and moderate hepatic impairment and healthy control subjects matched to the subjects in the moderate hepatic impairment category. The decision to commence Part 2 will be based on a review of the preliminary safety and pharmacokinetic data from subjects with moderate hepatic impairment. Part 2 will enroll subjects with severe hepatic impairment. Additionally, based on emergent data from Part 1, matched controls to the severe hepatic group may be enrolled (optional). Due to the potential difficulty in identifying eligible subjects with severe hepatic impairment, the study may be stopped prior to full enrollment in Part 2, provided that a minimum of 4 evaluable subjects with severe hepatic impairment have been enrolled. The study will consist of a Screening visit, a single dose Treatment Period and a Follow-up visit. Subjects will be screened for eligibility criteria within 30 days of enrolment. Subjects will be admitted to the clinical unit on Day -1; each subject will receive a single dose of GSK2336805 on Day 1 and will remain in the clinical unit for 5 days (check-out on Day 4). The follow-up visit will be conducted within 7-10 days after Day 1 dosing.

Conditions

Hepatitis C

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Part 1 Cohort 1 - Mild hepatic impairment

Subjects with mild hepatic impairment will be enrolled in Cohort 1 and will receive a single dose of 60 mg GSK2336805

Group Type: EXPERIMENTAL

GSK2336805

Intervention Type: DRUG

Two 30 mg GSK2336805 tablets for a 60 mg single dose will be administered in this study

Part 1 Cohort 2 - Moderate hepatic impairment

Subjects with moderate hepatic impairment will be enrolled in Cohort 2 and will receive a single dose of 60 mg GSK2336805

Group Type: EXPERIMENTAL

GSK2336805

Intervention Type: DRUG

Two 30 mg GSK2336805 tablets for a 60 mg single dose will be administered in this study

Part 1 Cohort 3 - Matched healthy volunteers to Cohort 2

Control subjects will be matched for gender, age (+/- 10 years), body mass index (BMI) (+/- 20%), and smoking status to the subjects in the moderate hepatic impairment arm. These healthy volunteers will receive a single dose of 60 mg GSK2336805

Group Type: EXPERIMENTAL

GSK2336805

Intervention Type: DRUG

Two 30 mg GSK2336805 tablets for a 60 mg single dose will be administered in this study

Part 2 Cohort 4 - Severe hepatic impairment

Subjects with severe hepatic impairment will be enrolled in Cohort 2 and will receive a single dose of 60 mg GSK2336805. The decision to move forward into Part 2 (severe hepatic impairment) will be based on a review of the preliminary safety and pharmacokinetic data from subjects with moderate hepatic impairment

Group Type: EXPERIMENTAL

GSK2336805

Intervention Type: DRUG

Two 30 mg GSK2336805 tablets for a 60 mg single dose will be administered in this study

Part 2 Cohort 5 - Matched healthy volunteers to Cohort 4

Based on emerging data from Part 1, the sponsor may decide to enroll matched controls to the severe hepatic group (i.e. in case of a change in dose or the demographics of the severe hepatic group are not well matched with the moderate control data). The subjects in this optional control cohort will be matched for gender, age (+/- 10 years), BMI (+/- 20%), and smoking status to the subjects in the severe hepatic impairment category

Group Type: EXPERIMENTAL

GSK2336805

Intervention Type: DRUG

Two 30 mg GSK2336805 tablets for a 60 mg single dose will be administered in this study

Interventions

GSK2336805

Two 30 mg GSK2336805 tablets for a 60 mg single dose will be administered in this study

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Male and female subjects aged 18 to 74 years inclusive, at the time of signing the informed consent.
• Body weight >=45 kilogram (kg) for men and women and body mass index (BMI) within the range 17- 41 kg/meter square (m^2) for hepatically impaired subjects; healthy matched control subjects will be matched to BMI +/- 20% and must also remain in the BMI range of 17- 41 kg/m^2.
• A female subject is eligible to participate if she is of non-childbearing potential (postmenopausal defined as 12 months of spontaneous amenorrhea or pre-menopausal females with a documented tubal ligation or hysterectomy).
• Male subjects with female partners of child-bearing potential must agree to use one of the contraception methods listed in the protocol. This criterion must be followed from the time of the first dose of study medication until the follow up visit.
• Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form.
• The subject is able to understand and comply with protocol requirements, instructions and protocol-stated restrictions and is likely to complete the study as planned.
• Ability and willingness to abstain from alcohol-containing beverages/foods from 48 hours prior to entry in the clinical study centre until discharge.
• Subjects whose platelets are greater than or equal to 30,000 x 10^9/Liter of blood who have not had any major bleeding episodes within the past 6 months.

Exclusion Criteria

• Pregnant females as determined by positive serum or urine Human Chorionic Gonadotropin (hCG) test at screening or prior to dosing.
• Lactating females.
• History of regular alcohol consumption within 6 months of the study defined as an average weekly intake of >14 drinks for males or >7 drinks for females. One drink is equivalent to 12 grams (g) of alcohol: 12 ounces (360 mL) of beer, 5 ounces (150 mL) of wine or 1.5 ounces (45 mL) of 80 proof distilled spirits.
• A positive test for human immunodeficiency virus (HIV) antibody.
• Where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day period.
• The subject has participated in a clinical trial and has received an investigational product within the following time period prior to the first dosing day in the current study: 30 days, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer).
• Consumption of red wine, seville oranges, grapefruit or grapefruit juice, pummelos, satsuma, ugli, tangerine, and tangelo, exotic citrus fruits, grapefruit hybrids or fruit juices from 7 days prior to the first dose of study medication.
• Use of prescription or non-prescription drugs, vitamins, and herbal and dietary supplements (including St John's Wort) within 7 days (or 14 days if the drug is a potential enzyme inducer) or 5 half-lives (whichever is longer) prior to the first dose of study medication. Hepatically impaired subjects requiring prescription or non-prescription drugs may be acceptable provided the medications are not on the Prohibited Medications List of the protocol and in the opinion of the Investigator the medication will not interfere with the study procedures or compromise subject safety.
• History or presence of allergy or intolerance to the study drugs or their components or drugs of their class, or a history of drug or other allergy that, in the opinion of the physician responsible, contraindicates their participation. In addition, if heparin is used during pharmacokinetic (PK) sampling, subjects with a history of sensitivity to heparin or heparin-induced thrombocytopenia should not be enrolled.
• The subject has a positive pre-study drug/alcohol screen. A minimum list of drugs that will be screened for include amphetamines, barbiturates, cocaine, opiates, cannabinoids and benzodiazepines. For hepatically impaired subjects, a positive drug screen will be allowed if it is due to a prescribed medication, provided that medication is not on the Prohibited Medications List of the protocol.
• Evidence of recent, acute infection with Hepatitis B and/or Hepatitis C within preceding 6 months. Subjects with chronic Hepatitis B or C (duration >6 months) are eligible for enrolment.
• Subjects with a pre-existing condition (except hepatic impairment) interfering with normal gastrointestinal anatomy or motility that could interfere with the absorption, metabolism, and/or excretion of the study drugs. Subjects with a history of inflammatory bowel disease should be excluded. Subjects with a history of peptic ulceration or pancreatitis within the preceding 6 months of screening should be excluded. Subjects with previous gastrointestinal (GI) surgery (except appendectomy or gall bladder removal more than three months prior to study) may be enrolled in this study only if, in the opinion of the Investigator and the Medical Monitor, it is not expected to interfere with the study procedures or to pose an additional safety risk to the subject.
• Subjects receiving lactulose who are medically unable to halt lactulose administration from 8 hour (h) before dosing with study drug to 4h after dosing with study drug.
• Subjects with severe encephalopathy (grade 3 or 4) as judged by the investigator or significant Central Nervous System (CNS) disease (e.g. dementia, or seizures) which the investigator considers will interfere with the informed consent, conduct, completion, or results of this trial or constitutes an unacceptable risk to the subject.
• Subjects with a change in dose regimen of medically required medication within the 2 weeks prior to dosing.
• Subjects with creatinine clearance <=50 mL/min (calculated by the Cockcroft-Gault Formula). If the result calculated by Cockcroft-Gault is between 40 and 50 mL/min, then the site may complete a 24 hour urine collection to more specifically calculate the CrCl. A CrCl value < or = 50mL/min via 24-hour urine collection is also exclusionary.
• History of gastric or esophageal variceal bleeding within the past 6 months and for which varices have not been adequately treated with medication and/or surgical procedures.
• Subjects with electrolyte imbalance whose serum sodium levels are less than or equal to 125 millimol/litre (mmol/L); potassium levels are less than or equal to 2.5 mmol/L; calcium levels less than or equal to 6.1mmol/L).
• Presence of hepatopulmonary or hepatorenal syndrome.
• Primarily cholestatic liver diseases.
• History of liver transplantation.
• Subjects in the severe hepatic impairment group that are expecting a liver transplant during the study participation period.
• Subjects with signs of active bacterial infection (including active spontaneous bacterial peritonitis).
• Subjects with Transjugular Intrahepatic Portosystemic Shunt (TIPS) placement within the past 3 months.
• Subjects with unstable cardiac function or subjects with hypertension whose blood pressure that is not well controlled (based on the investigator's discretion)
• Diabetic subjects whose diabetes that is not controlled (based on the investigator's discretion).

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 74 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

GlaxoSmithKline

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

GSK Clinical Trials

Role: STUDY_DIRECTOR

GlaxoSmithKline

Locations

GSK Investigational Site

Lakewood, Colorado, United States

GSK Investigational Site

Orlando, Florida, United States

GSK Investigational Site

Minneapolis, Minnesota, United States

GSK Investigational Site

Knoxville, Tennessee, United States

Countries

United States

Other Identifiers

117380

Identifier Type: -

Identifier Source: org_study_id