Trial Outcomes & Findings for Clinical Performance of a Transcutaneous Bone Conduction Hearing Solution (Baha® Attract System) (NCT NCT01822119)

NCT ID: NCT01822119

Last Updated: 2017-02-06

Results Overview

The change in pure-tone thresholds in free field measured by the difference in pure tone average PTA4 (Mean of thresholds at 500, 1000, 2000 and 4000 Hz) from the pre-operative unaided condition to the aided situation with the Baha Attract System at week 12.

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

27 participants

Primary outcome timeframe

Baseline before surgery and 12 weeks after surgery

Results posted on

2017-02-06

Participant Flow

Participant milestones

Participant milestones
Measure
Baha Attract System
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Overall Study
STARTED
27
Overall Study
COMPLETED
27
Overall Study
NOT COMPLETED
0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Clinical Performance of a Transcutaneous Bone Conduction Hearing Solution (Baha® Attract System)

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure
Baha Attract System
n=27 Participants
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Age, Continuous
45.7 years
STANDARD_DEVIATION 13.8 • n=5 Participants
Gender
Female
15 Participants
n=5 Participants
Gender
Male
12 Participants
n=5 Participants
Region of Enrollment
Hong Kong
8 participants
n=5 Participants
Region of Enrollment
Israel
6 participants
n=5 Participants
Region of Enrollment
Australia
8 participants
n=5 Participants
Region of Enrollment
Chile
5 participants
n=5 Participants
Type of hearing loss
Conductive hearing loss
17 participants
n=5 Participants
Type of hearing loss
Single-sided sensorineural deafness
10 participants
n=5 Participants

PRIMARY outcome

Timeframe: Baseline before surgery and 12 weeks after surgery

Population: Intention-to-Treat (ITT) population, includes all patients who received surgical intervention.

The change in pure-tone thresholds in free field measured by the difference in pure tone average PTA4 (Mean of thresholds at 500, 1000, 2000 and 4000 Hz) from the pre-operative unaided condition to the aided situation with the Baha Attract System at week 12.

Outcome measures

Outcome measures
Measure
Baha Attract System
n=27 Participants
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Hearing Performance, PTA4 at 12 Weeks
-18.4 dB
Standard Deviation 6.7

PRIMARY outcome

Timeframe: Baseline before surgery and 36 weeks after surgery

The change in pure-tone thresholds in free field measured by the difference in pure tone average PTA4 (Mean of thresholds at 500, 1000, 2000 and 4000 Hz) from the pre-operative unaided condition to the aided situation with the Baha Attract System at week 36.

Outcome measures

Outcome measures
Measure
Baha Attract System
n=27 Participants
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Hearing Performance, PTA4 at 36 Weeks
-18.4 dB
Standard Deviation 6.9

SECONDARY outcome

Timeframe: Baseline before surgery and 36 weeks after surgery

Population: Intention-to-Treat (ITT) population, includes all patients who received surgical intervention.

The change in pure-tone thresholds in free field measured by the difference at individual frequencies from the pre-operative unaided condition to the aided situation with the Baha Attract System at week 36.

Outcome measures

Outcome measures
Measure
Baha Attract System
n=27 Participants
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Hearing Performance, Individual Frequencies
Change in hearing level at 500HZ
-20.2 dB
Standard Deviation 14.4
Hearing Performance, Individual Frequencies
Change in hearing level at 1000HZ
-25.2 dB
Standard Deviation 8.4
Hearing Performance, Individual Frequencies
Change in hearing level at 2000HZ
-18.3 dB
Standard Deviation 9.5
Hearing Performance, Individual Frequencies
Change in hearing level at 3000HZ
-18.7 dB
Standard Deviation 14.7
Hearing Performance, Individual Frequencies
Change in hearing level at 4000HZ
-9.8 dB
Standard Deviation 10.8
Hearing Performance, Individual Frequencies
Change in hearing level at 6000HZ
-5.0 dB
Standard Deviation 12.3
Hearing Performance, Individual Frequencies
Change in hearing level at 8000HZ
-4.2 dB
Standard Deviation 10.7

SECONDARY outcome

Timeframe: Baseline before surgery and 36 weeks after surgery

Population: Intention-to-Treat population, includes all patients who received surgical intervention.

The change in pure-tone thresholds in free field measured by the difference in pure tone average PTA4 (Mean of thresholds at 500, 1000, 2000 and 4000 Hz) from the pre-operative aided situation with the Sound Processor on a softband to the aided situation with Baha Attract System at week 36.

Outcome measures

Outcome measures
Measure
Baha Attract System
n=27 Participants
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Hearing Performance, PTA4, Sound Processor on Softband Versus Baha Attract at 36 Weeks
0.926 dB
Standard Deviation 5.553

SECONDARY outcome

Timeframe: Baseline before surgery and 36 weeks after surgery

Population: Intention-to-Treat (ITT) population, includes all patients who received surgical intervention.

The change in pure-tone thresholds in free field measured by the difference in hearing levels of individual frequencies from the pre-operative aided situation with the Sound Processor on a softband to the aided situation with Baha Attract System at week 36.

Outcome measures

Outcome measures
Measure
Baha Attract System
n=27 Participants
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Hearing Performance, Individual Frequencies, Sound Processor on Softband Versus Baha Attract at 36 Weeks
500Hz
-0.741 dB
Standard Deviation 13.637
Hearing Performance, Individual Frequencies, Sound Processor on Softband Versus Baha Attract at 36 Weeks
1000Hz
-1.67 dB
Standard Deviation 7.34
Hearing Performance, Individual Frequencies, Sound Processor on Softband Versus Baha Attract at 36 Weeks
2000Hz
1.67 dB
Standard Deviation 7.07
Hearing Performance, Individual Frequencies, Sound Processor on Softband Versus Baha Attract at 36 Weeks
3000Hz
-0.37 dB
Standard Deviation 8.077
Hearing Performance, Individual Frequencies, Sound Processor on Softband Versus Baha Attract at 36 Weeks
4000Hz
4.44 dB
Standard Deviation 9.64
Hearing Performance, Individual Frequencies, Sound Processor on Softband Versus Baha Attract at 36 Weeks
6000Hz
6.92 dB
Standard Deviation 12.34
Hearing Performance, Individual Frequencies, Sound Processor on Softband Versus Baha Attract at 36 Weeks
8000
3.80 dB
Standard Deviation 12.10

SECONDARY outcome

Timeframe: Baseline before surgery and 36 weeks after surgery

Population: Intention-to-Treat (ITT) population, includes all patients who received surgical intervention.

The change in hearing performance, speech in quiet from the pre-operative unaided condition to the aided situation with the Baha Attract System at week 36.

Outcome measures

Outcome measures
Measure
Baha Attract System
n=27 Participants
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Hearing Performance, Speech in Quiet, Unaided Versus Baha Attract at 36 Weeks
Change at 50dB presentation level
50 % perception of presented words
Standard Deviation 23.7
Hearing Performance, Speech in Quiet, Unaided Versus Baha Attract at 36 Weeks
Change at 65dB presentation level
46.4 % perception of presented words
Standard Deviation 31.7
Hearing Performance, Speech in Quiet, Unaided Versus Baha Attract at 36 Weeks
Change at 80dB presentation level
24.2 % perception of presented words
Standard Deviation 25.6

SECONDARY outcome

Timeframe: Baseline before surgery and 36 weeks after surgery

Population: Intention-to-Treat (ITT) population, includes all patients who received surgical intervention.

The change in hearing performance, speech in quiet from the pre-operative aided situation with the Sond Processor on a softband to the aided situation with the Baha Attract System at week 36.

Outcome measures

Outcome measures
Measure
Baha Attract System
n=27 Participants
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Hearing Performance, Speech in Quiet, Aided With the Sound Processor on a Softband Versus Baha Attract at 36 Weeks
Change at 50dB presentation level
2.83 % perception of presented words
Standard Deviation 23.80
Hearing Performance, Speech in Quiet, Aided With the Sound Processor on a Softband Versus Baha Attract at 36 Weeks
Change at 65dB presentation level
0.98 % perception of presented words
Standard Deviation 13.49
Hearing Performance, Speech in Quiet, Aided With the Sound Processor on a Softband Versus Baha Attract at 36 Weeks
Change at 80dB presentation level
1.71 % perception of presented words
Standard Deviation 7.80

SECONDARY outcome

Timeframe: Baseline before surgery and 36 weeks after surgery

Population: Intention-to-Treat (ITT) population, includes all patients who received surgical intervention.

The change in hearing performance, speech in noise from the pre-operative unaided condition to the aided situation with the Baha Attract System at week 36.

Outcome measures

Outcome measures
Measure
Baha Attract System
n=27 Participants
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Hearing Performance, Speech in Noise, Unaided Versus Baha Attract at 36 Weeks
-15.0 Signal to noise ratio
Standard Deviation 12.8

SECONDARY outcome

Timeframe: Baseline before surgery and 36 weeks after surgery

Population: Intention-to-Treat (ITT) population, includes all patients who received surgical intervention.

The change in hearing performance, speech in noise from the pre-operative aided situation with the Sond Processor on a softband to the aided situation with the Baha Attract System at week 36.

Outcome measures

Outcome measures
Measure
Baha Attract System
n=27 Participants
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Hearing Performance, Speech in Noise, Aided With the Sound Processor on a Softband Versus Baha Attract at 36 Weeks
-3.79 Signal to noise ratio
Standard Deviation 6.96

SECONDARY outcome

Timeframe: Baseline before surgery and 36 weeks after surgery

Population: Intention-to-Treat (ITT) population, includes all patients who received surgical intervention.

Change of APHAB scoring from the unaided pre-operative situation to the aided situation with Baha Attract at 36 weeks. APHAB questionnaire is a 24-item self-assessment inventory that evaluates the benefit experienced by the patient when using hearing amplification compared to the unaided situation. APHAB produces a Global score and scores for four subscales: ease of communication (EC), reverberation (RV), background noise (BN), and aversiveness (AV). The absolute APHAB scale is between 0 and 100%, where 0% indicates no problem and 100% indicates always problem. The change from unaided to aided hearing is presented. A positive value indicates an improvement, a negative value an impairment. This scale applies to all reported scores.

Outcome measures

Outcome measures
Measure
Baha Attract System
n=27 Participants
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Abbreviated Profile of Hearing Aid Benefit (APHAB)
Aversiveness
-4.04 units on a scale
Standard Deviation 36.03
Abbreviated Profile of Hearing Aid Benefit (APHAB)
Ease of communication
4.23 units on a scale
Standard Deviation 52.16
Abbreviated Profile of Hearing Aid Benefit (APHAB)
Reverberation
5.10 units on a scale
Standard Deviation 42.78
Abbreviated Profile of Hearing Aid Benefit (APHAB)
Background noise
8.92 units on a scale
Standard Deviation 48.07
Abbreviated Profile of Hearing Aid Benefit (APHAB)
Global score
6.76 units on a scale
Standard Deviation 45.92

OTHER_PRE_SPECIFIED outcome

Timeframe: Visit 2 (surgery)

Population: Intention-to-Treat (ITT) population, includes all patients who received surgical intervention.

Outcome measures

Outcome measures
Measure
Baha Attract System
n=27 Participants
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Time to Perform Surgery
45.0 minutes
Standard Deviation 14.6

OTHER_PRE_SPECIFIED outcome

Timeframe: Visit 2 (surgery)

Population: Intention-to-Treat population, includes all patients who received surgical intervention.

Surgical thinning of the soft tissue flap was advocated when the soft tissue thickness exceeded 6 mm.

Outcome measures

Outcome measures
Measure
Baha Attract System
n=27 Participants
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Tissue Reduction Performed During Surgery
No tissue reduction
24 participants
Tissue Reduction Performed During Surgery
Tissue reduction
3 participants

OTHER_PRE_SPECIFIED outcome

Timeframe: Visit 2 (surgery)

Population: Intention-to-Treat (ITT) population, includes all patients who received surgical intervention.

Implant Stability Quotient - ISQ, a scale from 1 to 100, where 100 represent the highest stability.

Outcome measures

Outcome measures
Measure
Baha Attract System
n=27 Participants
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Implant Stability
75.7 units on a scale
Standard Deviation 8.8

OTHER_PRE_SPECIFIED outcome

Timeframe: Baseline

Population: Intention-to-Treat (ITT) population, includes all patients who received surgical intervention.

Type of sound processors BP100 and BP110 attached to a soft band (subject preference)

Outcome measures

Outcome measures
Measure
Baha Attract System
n=27 Participants
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Choice of Sound Processor
BP100
6 participants
Choice of Sound Processor
BP110
21 participants

OTHER_PRE_SPECIFIED outcome

Timeframe: Baseline before surgery and 12 weeks after surgery

Population: Intention-to-Treat (ITT) population, includes all patients who received surgical intervention.

Difference between softband measurement at visit 1 and measurement with the Baha Attract system at visit 6. Feedback is a measure of how much sound from the actuator (vibrator) returns to the microphones thus creating a loop of sound which sounds like high pitch noise. Measuring this is a part of the performance of the system, i.e how much gain can the sound processor produce before feedback occurs. Unit of measure is dB re output. A negative value of the change means less feedback.

Outcome measures

Outcome measures
Measure
Baha Attract System
n=27 Participants
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Feedback Measurement, BP100
400Hz
-13.2 dB
Standard Deviation 7.8
Feedback Measurement, BP100
500Hz
-6.54 dB
Standard Deviation 3.98
Feedback Measurement, BP100
630Hz
-4.29 dB
Standard Deviation 8.56
Feedback Measurement, BP100
800Hz
-7.11 dB
Standard Deviation 6.84
Feedback Measurement, BP100
1000Hz
-7.85 dB
Standard Deviation 4.59
Feedback Measurement, BP100
1250Hz
-10.1 dB
Standard Deviation 2.4
Feedback Measurement, BP100
1600Hz
-7.44 dB
Standard Deviation 2.88
Feedback Measurement, BP100
2000Hz
-2.82 dB
Standard Deviation 1.59
Feedback Measurement, BP100
2500Hz
-2.91 dB
Standard Deviation 3.64
Feedback Measurement, BP100
3150Hz
-1.21 dB
Standard Deviation 3.66
Feedback Measurement, BP100
4000Hz
1.83 dB
Standard Deviation 3.42
Feedback Measurement, BP100
5000Hz
0.17 dB
Standard Deviation 4.37
Feedback Measurement, BP100
6300Hz
7.28 dB
Standard Deviation 7.62
Feedback Measurement, BP100
8000Hz
3.95 dB
Standard Deviation 3.26

OTHER_PRE_SPECIFIED outcome

Timeframe: Baseline before surgery and 12 weeks after surgery

Population: Intention-to-Treat (ITT) population, includes all patients who received surgical intervention.

Difference between softband measurement at visit 1 and measurement with the Baha Attract system at visit 6. Feedback is a measure of how much sound from the actuator (vibrator) returns to the microphones thus creating a loop of sound which sounds like high pitch noise. Measuring this is a part of the performance of the system, i.e how much gain can the sound processor produce before feedback occurs. Unit of measure is dB re output. A negative value of the change means less feedback.

Outcome measures

Outcome measures
Measure
Baha Attract System
n=27 Participants
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Feedback Measurement, BP110
400Hz
-3.50 dB
Standard Deviation 8.36
Feedback Measurement, BP110
500Hz
-3.86 dB
Standard Deviation 8.46
Feedback Measurement, BP110
630Hz
-4.20 dB
Standard Deviation 10.59
Feedback Measurement, BP110
800Hz
-3.39 dB
Standard Deviation 9.16
Feedback Measurement, BP110
1000Hz
-5.03 dB
Standard Deviation 7.17
Feedback Measurement, BP110
1250Hz
-8.10 dB
Standard Deviation 7.87
Feedback Measurement, BP110
1600Hz
-8.85 dB
Standard Deviation 6.51
Feedback Measurement, BP110
2000Hz
-4.73 dB
Standard Deviation 4.65
Feedback Measurement, BP110
2500Hz
-3.08 dB
Standard Deviation 4.10
Feedback Measurement, BP110
3150Hz
-3.00 dB
Standard Deviation 3.30
Feedback Measurement, BP110
4000Hz
0.69 dB
Standard Deviation 4.86
Feedback Measurement, BP110
5000Hz
6.58 dB
Standard Deviation 6.24
Feedback Measurement, BP110
6300Hz
10.3 dB
Standard Deviation 4.7
Feedback Measurement, BP110
8000Hz
12.2 dB
Standard Deviation 9.7

OTHER_PRE_SPECIFIED outcome

Timeframe: Week 4, 6, 12 and 36

Population: Intention-to-Treat (ITT) population, includes all patients who received surgical intervention.

To investigate if the magnetic force required for sound processor magnet retention will change over time

Outcome measures

Outcome measures
Measure
Baha Attract System
n=27 Participants
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Magnetic Force
4 weeks
0.97 Newton
Standard Deviation 0.30
Magnetic Force
6 weeks
1.05 Newton
Standard Deviation 0.37
Magnetic Force
12 weeks
0.98 Newton
Standard Deviation 0.29
Magnetic Force
36 weeks
0.97 Newton
Standard Deviation 0.28

OTHER_PRE_SPECIFIED outcome

Timeframe: 36 weeks

Population: Intention-to-Treat (ITT) population, includes all patients who received surgical intervention.

Evaluation of the skin using the Patient and Observer Scar Assessment Scale (POSASa scale from 1 (normal skin) to 10 (worst scar imaginable).

Outcome measures

Outcome measures
Measure
Baha Attract System
n=27 Participants
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Safety; Skin Evaluation
Overall opinion observer
1.52 units on a scale
Standard Deviation 0.93
Safety; Skin Evaluation
Overall opinion patient
1.81 units on a scale
Standard Deviation 1.21

OTHER_PRE_SPECIFIED outcome

Timeframe: 36 weeks

Population: Intention-to-Treat (ITT) population, includes all patients who received surgical intervention.

Evaluation of neuropathic pain or pain in the scar the last week by asking the patients to rate their experience on a scale from 1 (no, not at all) to 10 (yes, very much).

Outcome measures

Outcome measures
Measure
Baha Attract System
n=27 Participants
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Safety; Pain
Neuropathic pain
1.19 units on a scale
Standard Deviation 0.79
Safety; Pain
Pain in the scar
1.15 units on a scale
Standard Deviation 0.77

OTHER_PRE_SPECIFIED outcome

Timeframe: 36 weeks

Population: Intention-to-Treat (ITT) population, includes all patients who received surgical intervention.

Evaluation of numbness by asking the patients if they had experienced any numbness within 2 cm from the centre of the implant magnet or within and beyond 2 cm from the centre of the implant magnet.

Outcome measures

Outcome measures
Measure
Baha Attract System
n=27 Participants
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Safety; Numbness
No numbness
21 participants
Safety; Numbness
Numbness within 2 cm
1 participants
Safety; Numbness
Numbness within 2 cm and beyond
5 participants

Adverse Events

Baha Attract System

Serious events: 2 serious events
Other events: 8 other events
Deaths: 0 deaths

Serious adverse events

Serious adverse events
Measure
Baha Attract System
n=27 participants at risk
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
Infections and infestations
Postoperative wound infection
7.4%
2/27 • Number of events 2 • 36 weeks
Injury, poisoning and procedural complications
Post procedural heamatoma
3.7%
1/27 • Number of events 1 • 36 weeks

Other adverse events

Other adverse events
Measure
Baha Attract System
n=27 participants at risk
This transcutaneous solution is based on a magnet coupling using magnets on both side of the skin; * One implant magnet * One external magnet on which a sound processor is attached, i.e. the Sound Processor magnet (SP magnet) Baha Attract System
General disorders
Application site pain
14.8%
4/27 • Number of events 4 • 36 weeks
General disorders
Implant site erythema
14.8%
4/27 • Number of events 4 • 36 weeks

Additional Information

Professor Robert Cowan

The HEARing CRC & Hearworks, Audiology Hearing and Speech Science, Melbourne, Australia

Phone: +61 3 9035 5346

Results disclosure agreements

  • Principal investigator is a sponsor employee
  • Publication restrictions are in place

Restriction type: GT60