Effect of Isoflurane on Tissue Doppler Imaging of Mitral Annulus During Cardiac Surgery
NCT ID: NCT01819012
Last Updated: 2016-11-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
20 participants
INTERVENTIONAL
2013-03-31
2014-03-31
Brief Summary
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Detailed Description
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Tissue Doppler imaging (TDI) of mitral annular velocity during the cardiac cycle has been introduced as a reliable method for analysis of systolic and diastolic LV long-axis function. Efficacy of systolic and diastolic TDI profiles, including systole (S'), early early relaxation (E')and atrial contraction (A') have been suggested to be useful in predicting the impact of isoflurane on LV systolic and diastolic function.
The investigators hypothesized that isoflurane, even at a clinical dosage, would affects intraoperative LV systolic function in a dose-dependent manner and thus produce significant changes int the TDI profiles of systolic mitral annular velocity (S').
So the investigators planned to study the changes in S' of lateral mitral annulus at the clinical isoflurane dosage during remifentanil based anesthesia for cardiac surgery.
Conditions
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Keywords
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Isoflurane 1.0 MAC
10 min-inhalation of each concentration of isoflurane, 1.0 MAC
Isoflurane 1.0 MAC
10 min-inhalation of each concentration of isoflurane, 1.0 MAC
Isoflurane 1.5 MAC
10 min-inhalation of each concentration of isoflurane, 1.5 MAC
Isoflurane 1.5 MAC
10 min-inhalation of each concentration of isoflurane, 1.5 MAC
Isoflurane 2.0 MAC
10 min-inhalation of each concentration of isoflurane, 2.0 MAC
Isoflurane 2.0 MAC
10 min-inhalation of each concentration of isoflurane, 2.0 MAC
Interventions
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Isoflurane 1.0 MAC
10 min-inhalation of each concentration of isoflurane, 1.0 MAC
Isoflurane 1.5 MAC
10 min-inhalation of each concentration of isoflurane, 1.5 MAC
Isoflurane 2.0 MAC
10 min-inhalation of each concentration of isoflurane, 2.0 MAC
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* atrial fibrillation
* pacemaker
* pericardial and infiltrative myocardial disease
* mitral annular calcification, surgical rings, prosthetic mitral valves
* lateral left ventricular regional wall motion abnormality
* esophageal spasm, stricture, laceration, perforation, and diverticulum diaphragmatic hernia
* history of extensive radiation to mediastinum
* upper gastrointestinal bleeding
20 Years
65 Years
ALL
No
Sponsors
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Konkuk University Medical Center
OTHER
Responsible Party
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Tae-Yop Kim, MD PhD
Professor of Anesthesiology
Principal Investigators
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Tae-Yop Kim, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Konkuk University
Locations
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Konkuk University Medical Center
Seoul, Seoul, South Korea
Countries
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References
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Kim JD, Son I, Kwon WK, Sung TY, Sidik H, Kim K, Kang H, Bang J, Yeo GE, Lee DK, Kim TY. Isoflurane's Effect on Intraoperative Systolic Left Ventricular Performance in Cardiac Valve Surgery Patients. J Korean Med Sci. 2018 Jan 22;33(4):e28. doi: 10.3346/jkms.2018.33.e28.
Other Identifiers
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KUH1160052
Identifier Type: -
Identifier Source: org_study_id