Can Genetics Predict Treatment Response to a Computerized Self-help Program for Depression?

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

500 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-03-31

Study Completion Date

2015-11-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The goal of this project is to determine whether genetic information can be used to predict response to an internet-based treatment of depression. Several studies now indicate that completing an internet-based treatment for depression, called Deprexis, can significantly improve symptoms of depression. However, not everyone improves. The purpose of this study is to determine whether genetic profile can predict who is likely to improve.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Internet Intervention for the Prevention of Depression - Approaches to Improving Mood

NCT01080105

Individuals at Risk for Depression

WITHDRAWN PHASE1

Effectiveness of Internet-based Depression Treatment

NCT01636752

Mild to Moderate Depressive Symptoms

COMPLETED NA

Behavioral Study to Predict the Efficacy of a Self-Help Tool

NCT06631183

Self-reported Symptoms of Depression

ACTIVE_NOT_RECRUITING NA

Internet-Based Treatment of Depression: Comparing Guided With Unguided Self-Help

NCT04428450

Depression

COMPLETED NA

Effectiveness of Internet-based Depression Treatment (EVIDENT) in Severe Depression

NCT02178631

Severe Depressive Symptoms

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Major Depressive Disorder Mood Disorders

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Computerized self-help program for depression

Participants will have access to a computerized self-help program for depression, called deprexis, for 8 weeks.

Group Type ACTIVE_COMPARATOR

Computerized self-help program for depression

Intervention Type BEHAVIORAL

For 8 weeks, participants will engage in a computerized self-help program for depression, called deprexis. This program consists of 10 content modules representing different psychotherapeutic approaches broadly consistent with a cognitive-behavioral perspective. Modules are organized as simulated dialogues in which the program explains and illustrates concepts and techniques, engages the user in exercises, and continuously asks users to respond by selecting from response options. Subsequent content is then tailored to the users' responses, resulting in a simulated conversational flow. Participants can access the self-help program as often as they would like and since it is self-guided, they will determine how often they access the material. Each module can be completed in 10 to 60 minutes, depending on the user's reading speed, interest, motivation, and individual path through the program.

Wait List Control

Participants randomly assigned to a "wait list control" condition will wait 8 weeks after assignment before they can access the deprexis program.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Computerized self-help program for depression

For 8 weeks, participants will engage in a computerized self-help program for depression, called deprexis. This program consists of 10 content modules representing different psychotherapeutic approaches broadly consistent with a cognitive-behavioral perspective. Modules are organized as simulated dialogues in which the program explains and illustrates concepts and techniques, engages the user in exercises, and continuously asks users to respond by selecting from response options. Subsequent content is then tailored to the users' responses, resulting in a simulated conversational flow. Participants can access the self-help program as often as they would like and since it is self-guided, they will determine how often they access the material. Each module can be completed in 10 to 60 minutes, depending on the user's reading speed, interest, motivation, and individual path through the program.

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* English-speaking
* Have reliable access to the internet (i.e., dialup or broadband access)
* Be willing to donate saliva for DNA research
* Have a current symptoms of depression
* Be stable on medication and/or therapy (i.e. no changes within 2 weeks of study entry)

Exclusion Criteria

* Any diagnosis of a psychotic or bipolar disorder
* Meeting for alcohol/drug dependence in the past year
* Having current suicidal risk warranting crisis intervention

Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No