Comparison of TRIA-662 500 mg and Niaspan 1000 mg in Healthy Male and Female Volunteers Under Fed Conditions

NCT ID: NCT01809301

Last Updated: 2013-08-22

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-03-31
• Study Completion Date: 2013-05-31

Brief Summary

The objective of this study is to compare the absorption of a niacin metabolite (1-methylnicotinamide, 1-MNA) from TRIA-662 (1-methylnicotinamide chloride)relative to the production of 1-MNA from Niaspan. The 1-MNA information obtained from this study will be used to adjust the top dose of a planned TRIA-622 efficacy study.

Conditions

Healthy

Keywords

Bioavailability

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Blinding Strategy: NONE

Study Groups

Niaspan

Single dose of one NIASPAN® 1000 mg Extended-Release Tablet following dinner

Group Type: ACTIVE_COMPARATOR

Niaspan

Intervention Type: DRUG

TRIA-662

Single dose of two TRIA-662, 500 mg Immediate-Release Tablets following dinner

Group Type: EXPERIMENTAL

TRIA-662

Intervention Type: DRUG

Interventions

Niaspan

Intervention Type: DRUG

TRIA-662

Intervention Type: DRUG

Other Intervention Names

Extended-release nicotinic acid; Extended-release niacin; 1-methynicotinamide chloride; N-methylnicotinamide chloride; MNA chloride; 1-MNA chloride

Eligibility Criteria

Inclusion Criteria

1. Healthy, non-smoking (for at least 6 months prior to drug administration), male and female volunteers, 35-65 years of age, inclusive.

2. Body weight within 30% of ideal body weight.

3. Healthy, according to the medical history, ECG, vital signs, laboratory results and physical examination as determined by the Principal Investigator/Sub-Investigator.

4. Systolic blood pressure between 100-140 mmHg, inclusive, and diastolic blood pressure between 60-90 mmHg, inclusive, and heart rate between 50-100 bpm, inclusive, unless deemed otherwise by the Principal Investigator/Sub-Investigator.

Exclusion Criteria

1. Known history or presence of any clinically significant hepatic (e.g. active liver disease, hepatic necrosis, jaundice, hepatobiliary disease, hepatic dysfunction), renal/genitourinary (e.g. renal impairment, renal dysfunction), gastrointestinal, cardiovascular (e.g. angina, myocardial infarction), cerebrovascular, pulmonary, endocrine (e.g. diabetes, hypophosphatemia,), immunological, musculoskeletal (e.g. rhabdomyolysis, myopathy), neurological, psychiatric, dermatological or hematological or condition unless determined as not clinically significant by the Principal Investigator/Sub-Investigator.

2. Clinically significant history or presence of any clinically significant gastrointestinal pathology (e.g. chronic diarrhea, inflammatory bowel disease), unresolved gastrointestinal symptoms (e.g. diarrhea, vomiting), or other conditions known to interfere with the absorption, distribution, metabolism or excretion of the drug experienced within 7 days prior to first drug administration, as determined by the Principal Investigator/Sub-Investigator.

3. Known presence of active bleeding.

4. Known history or presence of:

• Alcohol abuse or dependence within one year prior to drug administration.
• Drug abuse or dependence.
• Hypersensitivity or idiosyncratic reaction to niacin, its excipients (e.g. methyl cellulose, povidone, stearic acid), and/or related substances (e.g. nicotinamide [Vit. B3]).
• Hypertension requiring treatment
• Active peptic ulcer
• Hypo or hyperthyroidism not treated or not stable for at least 6 months
• Gout
• Food allergies and/or presence of any dietary restrictions.
• Severe allergic reactions (e.g. anaphylactic reactions, angioedema).

5. Intolerance to and/or difficulty with blood sampling through venipuncture.

6. Use of any prescription medication within 30 days prior to drug administration (except for hormonal contraceptives).

7. Use of any over-the-counter medications or vitamins (including herbal and/or dietary supplements and/or teas) within 14 days prior to drug administration (except for spermicidal/barrier contraceptive products).

8. Use of any statins (e.g. lovastatin, simvastatin), bile acid sequestrants (e.g. cholestyramine), aspirin, antihypertensive therapy, vasoactive drugs (e.g. nitrates), calcium channel blockers, adrenergic blocking agents, anticoagulants and vitamins (e.g. multivitamins) within 30 days prior to drug administration.

9. Women who are pregnant, planning to become pregnant during the study or are nursing.

• Minimum Eligible Age: 35 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

PPD Development, LP

INDUSTRY

Sponsor Role: collaborator

Pharmena North America

INDUSTRY

Sponsor Role: collaborator

Cortria Corporation

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Eugenio A Cefali, PharmD, PhD.

Role: STUDY_CHAIR

Cortria Corporation

Locations

Bio Pharma Services Inc. (BPSI)

Toronto, Ontario, Canada

Countries

Canada

Other Identifiers

BPSI-1479

Identifier Type: -

Identifier Source: org_study_id