Preoperative Oral Immunonutrition for Patients With Pancreatic Cancer Undergoing Elective Surgery - Effect on Complications and Length of Hospital Stay

NCT ID: NCT01789073

Last Updated: 2013-12-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

35 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-02-28

Study Completion Date

2013-12-31

Brief Summary

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The purpose of this study is to investigate the effect of preoperative immunonutrition on complications and length of hospital stay in patients with pancreatic cancer undergoing elective surgery.

Detailed Description

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Conditions

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Pancreatic Cancer

Keywords

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Postoperative Complications Elective Surgery GI surgery Immunonutrition Immune-enhancing Immune-modulating Nutrition Pancreatic cancer Postoperative complications and length of hospital stay after major gastrointestinal (GI) elective surgery.

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Oral Impact, Nestlé Health Science

Oral Impact-arm receives the intervention the last 7 days prior to surgery

Group Type EXPERIMENTAL

Oral Impact, Nestlé Health Science

Intervention Type DIETARY_SUPPLEMENT

Oral Impact from Nestlé Health Science. An enteral nutritional supplement high in protein and with added immune-enhancing nutrients: arginine, fish oil and nucleotides. The intervention arm receives Oral Impact in an individually estimated dosage according to a protein requirement of 1.5 g/kg bodyweight/day (subtracted their habitual protein intake). Each patient receives this dosage orally the last 7 days prior to surgery.

Control

The control-arm receives no intervention but is treated according to the standard procedures

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Oral Impact, Nestlé Health Science

Oral Impact from Nestlé Health Science. An enteral nutritional supplement high in protein and with added immune-enhancing nutrients: arginine, fish oil and nucleotides. The intervention arm receives Oral Impact in an individually estimated dosage according to a protein requirement of 1.5 g/kg bodyweight/day (subtracted their habitual protein intake). Each patient receives this dosage orally the last 7 days prior to surgery.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Men and women referred to treatment at Surgical Gastroenterology Clinic C, Ward 2122 for pancreatic cancer
* Age \> 18 years.

Exclusion Criteria

* Age \< 18 years
* Pregnant and lactating women
* Persons who cannot understand and/or speak Danish
* Renal dysfunction
* Milk allergy
* Participants are excluded if elective surgery is not indicated after all
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Rigshospitalet, Denmark

OTHER

Sponsor Role collaborator

University of Copenhagen

OTHER

Sponsor Role lead

Responsible Party

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Arne Astrup

Chief of Institute of Human Nutrition

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jens R Andersen, Chief Phys., Ass. Prof.

Role: PRINCIPAL_INVESTIGATOR

University of Copenhagen

Locations

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Surgical Gastroenterology Clinic C, Ward 2122, Rigshospitalet

Copenhagen, , Denmark

Site Status

Countries

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Denmark

References

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Gade J, Levring T, Hillingso J, Hansen CP, Andersen JR. The Effect of Preoperative Oral Immunonutrition on Complications and Length of Hospital Stay After Elective Surgery for Pancreatic Cancer--A Randomized Controlled Trial. Nutr Cancer. 2016;68(2):225-33. doi: 10.1080/01635581.2016.1142586. Epub 2016 Mar 4.

Reference Type DERIVED
PMID: 26943500 (View on PubMed)

Other Identifiers

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H-1-2012-146

Identifier Type: -

Identifier Source: org_study_id