Evaluation of the Sphingolipid Metabolite S1P as a Novel Biomarker in Food Allergy
NCT ID: NCT01776489
Last Updated: 2015-12-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
70 participants
OBSERVATIONAL
2011-12-31
2017-01-31
Brief Summary
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Recent studies have revealed that sphingolipids, especially sphingosine-1-phosphate (S1P), play an essential role in allergy. It was reported that asthmatic patients have higher S1P levels in bronchiallavage fluids after allergen challenge. First experimental studies revealed a correlation of S1P and the outcome of anaphylaxis. Furthermore, we have shown in our recent mouse study that S1P homeostasis is pivotal for food allergy induction and effector cell response. Therefore, it is the aim of the presented pilot project to evaluate whether S1P serum titers are altered in food allergic children and if the S1P levels correlate with the outcome of anaphylaxis during double blind placebo controlled food challenges (DBPCFCs).
Detailed Description
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Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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food allergic
positive reaction during DBPCFC
No interventions assigned to this group
Non-food allergic
no reaction during DBPCFC
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Patients who are diagnosed by elevated allergen specific IgE and/or positive skin prick testing
* Willingness to participate in the study
Exclusion Criteria
* Non-IgE-mediated food allergy
12 Months
17 Years
ALL
No
Sponsors
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Medical University of Vienna
OTHER
Responsible Party
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Eva Untersmayr-Elsenhuber
Assoc. Prof., Dr.
Principal Investigators
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Eva Untersmayr-Elsenhuber, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Medical University Vienna, Department of Pathophysiology and Allergy Research
Locations
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Medical University Vienna, Department of Pediatrics and Adolescent Medicine
Vienna, , Austria
Countries
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Central Contacts
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References
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Diesner SC, Olivera A, Dillahunt S, Schultz C, Watzlawek T, Forster-Waldl E, Pollak A, Jensen-Jarolim E, Untersmayr E, Rivera J. Sphingosine-kinase 1 and 2 contribute to oral sensitization and effector phase in a mouse model of food allergy. Immunol Lett. 2012 Jan 30;141(2):210-9. doi: 10.1016/j.imlet.2011.10.006. Epub 2011 Oct 14.
Olivera A, Eisner C, Kitamura Y, Dillahunt S, Allende L, Tuymetova G, Watford W, Meylan F, Diesner SC, Li L, Schnermann J, Proia RL, Rivera J. Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice. J Clin Invest. 2010 May;120(5):1429-40. doi: 10.1172/JCI40659. Epub 2010 Apr 19.
Olivera A, Mizugishi K, Tikhonova A, Ciaccia L, Odom S, Proia RL, Rivera J. The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis. Immunity. 2007 Mar;26(3):287-97. doi: 10.1016/j.immuni.2007.02.008. Epub 2007 Mar 8.
Ammit AJ, Hastie AT, Edsall LC, Hoffman RK, Amrani Y, Krymskaya VP, Kane SA, Peters SP, Penn RB, Spiegel S, Panettieri RA Jr. Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma. FASEB J. 2001 May;15(7):1212-4. doi: 10.1096/fj.00-0742fje. No abstract available.
Related Links
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study center
study center
project homepage
Other Identifiers
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KLI 284-B00
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
119/2011
Identifier Type: -
Identifier Source: org_study_id