The Effect of n-3 Fatty Acids and Fish on Glucose and Lipid Metabolism in Subjects With Impaired Glucose Metabolism
NCT ID: NCT01768429
Last Updated: 2014-12-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
79 participants
INTERVENTIONAL
2012-10-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
NONE
Study Groups
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Fatty fish
Four fatty fish meals per week
Fatty fish
Lean Fish
Four lean fish meals per week
Lean Fish
Alpha-linolenic acid
10 g of alpha-linolenic acid daily from camelina sativa oil
Alpha-linolenic acid
Control diet
Limited fish and alpha-linolenic acid intake
Control
Interventions
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Fatty fish
Lean Fish
Alpha-linolenic acid
Control
Eligibility Criteria
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Inclusion Criteria
* BMI 25-32 kg/m2
* fasting plasma glucose 5.6-7.0 mmol/l
* 2 h plasma glucose in oral glucose tolerance test \<=11 mmol/l
* fasting serum total cholesterol \<=7 mmol/l
* fasting serum LDL cholesterol \<=5 mmol/l
* fasting serum triglycerides \<=4 mmol/l
Exclusion Criteria
* chronic liver, thyroid or kidney disease
* alcohol abuse
* diabetes
* recent weight loss
* recent myocardial infarction
* corticosteroid therapy
* psychiatric disorders which need drug treatment
* cancer under treatment
* fish allergy or other extensive food allergies
* exceptional diets (like Atkin's or vegan diet)
40 Years
70 Years
ALL
No
Sponsors
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Kuopio University Hospital
OTHER
VTT Technical Research Centre, Finland
OTHER
University of Eastern Finland
OTHER
Responsible Party
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Principal Investigators
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Arja Erkkilä, Adjunct Prof
Role: PRINCIPAL_INVESTIGATOR
University of Eastern Finland
Ursula Schwab, Adjunct Prof
Role: PRINCIPAL_INVESTIGATOR
University of Eastern Finland
Locations
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University of Eastern Finland
Kuopio, , Finland
Countries
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References
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Meuronen T, Lankinen MA, Fauland A, Shimizu BI, de Mello VD, Laaksonen DE, Wheelock CE, Erkkila AT, Schwab US. Intake of Camelina Sativa Oil and Fatty Fish Alter the Plasma Lipid Mediator Profile in Subjects with Impaired Glucose Metabolism - A Randomized Controlled Trial. Prostaglandins Leukot Essent Fatty Acids. 2020 Aug;159:102143. doi: 10.1016/j.plefa.2020.102143. Epub 2020 May 30.
Manninen S, Lankinen M, Erkkila A, Nguyen SD, Ruuth M, de Mello V, Oorni K, Schwab U. The effect of intakes of fish and Camelina sativa oil on atherogenic and anti-atherogenic functions of LDL and HDL particles: A randomized controlled trial. Atherosclerosis. 2019 Feb;281:56-61. doi: 10.1016/j.atherosclerosis.2018.12.017. Epub 2018 Dec 23.
Manninen S, Lankinen M, de Mello V, Agren J, Laaksonen D, Schwab U, Erkkila A. The effect of camelina sativa oil and fish intakes on fatty acid compositions of blood lipid fractions. Nutr Metab Cardiovasc Dis. 2019 Jan;29(1):51-61. doi: 10.1016/j.numecd.2018.10.002. Epub 2018 Oct 11.
Manninen SM, Lankinen MA, de Mello VD, Laaksonen DE, Schwab US, Erkkila AT. Intake of Fatty Fish Alters the Size and the Concentration of Lipid Components of HDL Particles and Camelina Sativa Oil Decreases IDL Particle Concentration in Subjects with Impaired Glucose Metabolism. Mol Nutr Food Res. 2018 May;62(10):e1701042. doi: 10.1002/mnfr.201701042.
Other Identifiers
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ALFAKALA
Identifier Type: -
Identifier Source: org_study_id