DOREFA (Retinal Detachment: Function and Anatomy)

NCT ID: NCT01767038

Last Updated: 2018-12-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

202 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-11-30

Study Completion Date

2015-05-31

Brief Summary

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Patients with retinal detachment do not always recover good visual function. Sometimes simple causes are responsible. Other causes can only be discovered thanks to high-resolution imaging provided by the latest generation of OCT.

This study is possible thanks to surgical teams who have a strong recruitment potential, with the experience of a joint project in 2007-2008 (PHRC national - Etude DOREMY, Etude FRIENDS) to define more strict intervention criteria. The principal objective of this study is to better define with regard to time:

* The onset of surgically curable or transient macular affections, and losses in visual acuity that can be qualified as "explained"
* But above all to better understand the relationships between anatomical analyses obtained using OCT and autofluorescence and functional analysis using visual acuity and microperimetry.
* In the near future, two techniques (OCT and microperimetry) will certainly become essential tools in the evaluation of macular function. Better understanding of these relationships is the first necessary step in any study concerning the therapeutic prevention of retinal lesions related to retinal detachment: This study will make it possible to define criteria for the evaluation of anatomical and functional recovery, their relationship with each other and finally their evolution over time. This is an essential first phase before possible therapies can be evaluated.

Detailed Description

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Conditions

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Retinal Detachment

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Blinding Strategy

NONE

Interventions

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OCT Spectralis

Intervention Type PROCEDURE

microperimetry

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients who have provided written informed consent
* Retinal detachment with pre-operative raised macula, re-attached during a surgical intervention with one month of follow-up
* Patients undergoing surgery as the first-line treatment (ab extern surgery or gas vitrectomy)
* Patients who accept to be followed for at least 12 months at the investigating center.

Exclusion Criteria

* Persons who are not registered with social security agency
* Macular affections pre-existent to the DR
* Retinal detachment requiring several interventions to obtain a reapplication
* Lazy eye with pre-operative
* Brightness of the circles not allowing the realization of the examinations
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Universitaire Dijon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHU Besançon

Besançon, , France

Site Status

CHU Bordeaux

Bordeaux, , France

Site Status

CHU Dijon

Dijon, , France

Site Status

CHU Grenoble

Grenoble, , France

Site Status

CHU Nancy

Nancy, , France

Site Status

CHU Nantes

Nantes, , France

Site Status

Hôpital Lariboisière

Paris, , France

Site Status

Fondation Ophtalmologique Adolphe de Rothschild

Paris, , France

Site Status

CHU Reims - Hôpital Robert Debré

Reims, , France

Site Status

CHU Strasbourg - Hôpital Civil

Strasbourg, , France

Site Status

Countries

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France

Other Identifiers

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Creuzot-Garcher PHRC N 2010

Identifier Type: -

Identifier Source: org_study_id