Noninterventional Examination of Subcutaneous (sc) Tumor Necrosis Factor (TNF) Inhibitors

NCT ID: NCT01764321

Last Updated: 2020-12-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1723 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-12-31

Study Completion Date

2020-06-16

Brief Summary

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This prospective, post marketing, observational, Noninterventional Study (NIS) is designed to compare drug persistence in patients treated with Certolizumab Pegol (CZP) and patients treated with any other subcutaneously (sc) administered Tumor Necrosis Factor (TNF) inhibitor.

Detailed Description

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Conditions

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Rheumatoid Arthritis

Keywords

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Certolizumab Pegol Cimzia® TNF inhibitor DMARD Rheumatoid Arthritis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Certolizumab Pegol treatment

Certolizumab Pegol in combination with at least one Disease Modifying Antirheumatic Drug (DMARD)

No interventions assigned to this group

Other Tumor Necrosis Factor TNF inhibitor treatment

Other subcutaneous (sc) Tumor Necrosis Factor (TNF) inhibitor (Adalimumab, Golimumab, Etanercept) in combination with at least one Disease Modifying Antirheumatic Drug (DMARD)

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of Rheumatoid Arthritis (RA)
* Moderate to severe disease activity of RA
* The patient receives Tumor Necrosis Factor (TNF) inhibitor in combination with at least 1 synthetic Disease Modifying Antirheumatic Drug (DMARD)
* The decision to prescribe a TNF inhibitor in combination with DMARD is made by the treating physician, prior to and independently from the decision to include the patient in this Non-Interventional Study (NIS)
* Male or female patients ≥ 18 years of age, considered by the treating physician to be reliable and capable of adhering to the observational plan (eg, able to understand and complete questionnaires)
* The patient personally signed and dated Patient Data Consent Form (PDCF) prior to Visit 2
* Treatment is according to the Summary of Product Characteristics (SmPC)

Exclusion Criteria

* Known contraindications to Tumor Necrosis Factor (TNF) inhibitors
* Prior use of any TNF inhibitors (including Adalimumab, Etanercept, Infliximab, Certolizumab, or Golimumab), or other biologic DMARDs (including Abatacept, Rituximab, Tocilizumab, or Anakinra)
* Participation in an investigational study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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UCB Pharma SA

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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UCB Cares

Role: STUDY_DIRECTOR

+1 844 599 2273 (UCB)

Locations

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039

Aachen, , Germany

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Aachen, , Germany

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Altenburg, , Germany

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044

Altenholz, , Germany

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Amberg, , Germany

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Bad Bramstedt, , Germany

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Bad Doberan, , Germany

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Bad Homburg, , Germany

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Bad Kreuznach, , Germany

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Bad Kreuznach, , Germany

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Bad Nauheim, , Germany

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Bad Neuenahr-Ahrweiler, , Germany

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Bad Pyrmont, , Germany

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Bautzen, , Germany

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Bautzen, , Germany

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Bayreuth, , Germany

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Bayreuth, , Germany

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Berlin, , Germany

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Berlin, , Germany

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Berlin, , Germany

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Berlin, , Germany

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Berlin, , Germany

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Berlin, , Germany

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Berlin, , Germany

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Berlin, , Germany

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Berlin, , Germany

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Berlin, , Germany

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Bochum, , Germany

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Braunschweig, , Germany

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021

Burghausen, , Germany

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Chemnitz, , Germany

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Cottbus, , Germany

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Darmstadt, , Germany

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Donaueschingen, , Germany

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Dresden, , Germany

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Dresden, , Germany

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Düsseldorf, , Germany

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Elmshorn, , Germany

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Erfurt, , Germany

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Erlangen, , Germany

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Essen, , Germany

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Frankenberg, , Germany

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Frankfurt, , Germany

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Frankfurt, , Germany

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Freiberg, , Germany

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041

Freiburg im Breisgau, , Germany

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Freiburg im Breisgau, , Germany

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Friedrichroda, , Germany

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Geilenkirchen, , Germany

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Geislingen an der Steige, , Germany

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133

Giessen, , Germany

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Giessen, , Germany

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143

Goslar, , Germany

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032

Göttingen, , Germany

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Greifswald, , Germany

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029

Halle, , Germany

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Halle, , Germany

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002

Hamburg, , Germany

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Hamburg, , Germany

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Hamburg, , Germany

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Hamburg, , Germany

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070

Hamburg, , Germany

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Hanover, , Germany

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Hanover, , Germany

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048

Heidelberg, , Germany

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057

Heidelberg, , Germany

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Herne, , Germany

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043

Hildesheim, , Germany

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053

Hofheim, , Germany

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092

Hoyerswerda, , Germany

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096

Jena, , Germany

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180

Karlsruhe, , Germany

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184

Kronach, , Germany

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004

Leipzig, , Germany

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068

Leipzig, , Germany

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013

Ludwigsfelde, , Germany

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114

Lübeck, , Germany

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034

Magdeburg, , Germany

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177

Mainz, , Germany

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195

Mansfeld, , Germany

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028

Marktredwitz, , Germany

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049

Mittelherwigsdorf, , Germany

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055

Mönchengladbach, , Germany

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015

München, , Germany

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München, , Germany

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093

München, , Germany

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München, , Germany

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München, , Germany

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Naunhof, , Germany

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Neubrandenburg, , Germany

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Neuss, , Germany

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090

Neuss, , Germany

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Nienburg, , Germany

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076

Offenburg, , Germany

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035

Planegg, , Germany

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097

Plauen, , Germany

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051

Potsdam, , Germany

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187

Potsdam, , Germany

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061

Püttlingen, , Germany

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185

Radebeul, , Germany

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123

Rendsburg, , Germany

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118

Rostock, , Germany

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112

Saarbrücken, , Germany

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121

Schwerin, , Germany

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122

Schwerin, , Germany

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144

Schwerin, , Germany

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Seesen, , Germany

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115

Stadtbergen, , Germany

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171

Stolberg, , Germany

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074

Stuttgart, , Germany

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146

Stuttgart, , Germany

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085

Traunstein, , Germany

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152

Treuenbrietzen, , Germany

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009

Tübingen, , Germany

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059

Tübingen, , Germany

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077

Weener, , Germany

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113

Winsen, , Germany

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065

Wuppertal, , Germany

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106

Würselen, , Germany

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042

Würzburg, , Germany

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182

Zwickau, , Germany

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001

Zwiesel, , Germany

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Countries

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Germany

Other Identifiers

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RA0097

Identifier Type: -

Identifier Source: org_study_id