Single and Multiple Dose Pharmacokinetics of Sufentanil NanoTab

NCT ID: NCT01761565

Last Updated: 2015-10-01

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-01-31

Study Completion Date

2013-02-28

Brief Summary

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Determine the plasma concentration profile after single and multiple dosing of Sufentanil NanoTabs

Detailed Description

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Conditions

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Plasma Concentrations

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Single dose of SUF NT 15 mcg then 40 doses of SUF NT 15 mcg

Period 1: Single dose of SUF NT 15 mcg

Period 2: 40 consecutive doses of SUF NT 15 mcg taken every 20 minutes

Group Type EXPERIMENTAL

Single dose of SUF NT 15 mcg

Intervention Type DRUG

40 consecutive doses of SUF NT 15 mcg taken every 20 minutes

Intervention Type DRUG

Interventions

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Single dose of SUF NT 15 mcg

Intervention Type DRUG

40 consecutive doses of SUF NT 15 mcg taken every 20 minutes

Intervention Type DRUG

Other Intervention Names

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Zalviso™

Eligibility Criteria

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Inclusion Criteria

* Non smoking
* Ages 18 to 45 year, inclusive
* BMI between 18 and 30

Exclusion Criteria

* Subjects taking any prescription or OTC medications or vitamins or supplements
* Pregnant females
* Subjects with pulmonary disease or sleep apnea
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Talphera, Inc

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sandra K. Willsie, D.O.

Role: PRINCIPAL_INVESTIGATOR

PRA

Locations

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PRA

Lenexa, Kansas, United States

Site Status

Countries

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United States

References

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Willsie SK, Evashenk MA, Hamel LG, Hwang SS, Chiang YK, Palmer PP. Pharmacokinetic properties of single- and repeated-dose sufentanil sublingual tablets in healthy volunteers. Clin Ther. 2015 Jan 1;37(1):145-55. doi: 10.1016/j.clinthera.2014.11.001. Epub 2014 Dec 24.

Reference Type BACKGROUND
PMID: 25544247 (View on PubMed)

Other Identifiers

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IAP101

Identifier Type: -

Identifier Source: org_study_id

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