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inflAmmatory maRkers in Blood and Thrombus Aspirated From Patients With acutE myocaRdial Infarction With St-segment elevAtion

NCT ID: NCT01757886

Last Updated: 2012-12-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-11-30

Study Completion Date

2013-11-30

Brief Summary

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The prognostic value of inflammatory markers in acute coronary syndrome has been extensively demonstrated, however it is still unknown whether there is an association between circulating and local (thrombus) inflammatory molecules, and the subset of molecules that provide better prognostic information in patients with ST-elevation acute coronary syndrome.

Detailed Description

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Conditions

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Patients Admitted With the Diagnosis of ST-elevation Acute Coronary Syndrome

Keywords

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Myocardial infarction, Inflammation, Thrombus, Coronary angioplasty.

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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ST-elevation acute coronary syndrome

ARTERY is a prospective, multicenter, which will include patients admitted with the diagnosis of ST-elevation acute coronary syndrome and thrombus aspiration is performed during primary angioplasty

Biomarkers to analyze both intracoronary thrombi as blood

Intervention Type OTHER

Interventions

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Biomarkers to analyze both intracoronary thrombi as blood

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* They include patients of both sexes, without limits of age, with a diagnosis of STEMI within 12 hours after the beginning of symptoms. ST-elevation myocardial infarction was defined in the presence of symptoms consistent, persistent elevation (\> 20 min) ST segment ≥ 1 mm in at least two contiguous leads or in the presence of left bundle branch block presumably new onset and cardiac troponin I elevation

Exclusion Criteria

* Injury significant common core of left coronary artery (stenosis greater than or equal to 50% of the vessel lumen).
* Pre-Fibrinolysis percutaneous coronary intervention.
* Previous coronary bypass surgery.
* Thyrotoxicosis.
* Having an inflammatory systemic or local inflammatory process.
* Malignant neoplasm.
* Any disease that seriously compromise the prognosis and / or systemic inflammatory response generated.
* No thrombotic material obtained in the thrombus or insufficient for performing biochemical determinations.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fundación Canaria Rafael Clavijo para la Investigación Biomédica

OTHER

Sponsor Role lead

Responsible Party

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Enrique Quintero

Alberto Dominguez Rodriguez

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Alberto Dominguez-Rodriguez, MD, PhD

Role: STUDY_CHAIR

Hospital Universitario de Canarias

Locations

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Hospital Universitario de Canarias

San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain

Site Status RECRUITING

Hospital Universitario de Canarias

San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain

Site Status RECRUITING

Hospital Universitario de Canarias

San Cristóbal de La Laguna, Tenerife, Spain

Site Status RECRUITING

Countries

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Spain

Central Contacts

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Alberto Dominguez-Rodriguez, MD, PhD

Role: CONTACT

Phone: +34 922 679040

Email: [email protected]

Facility Contacts

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Alberto Dominguez-Rodriguez, MD, PhD

Role: primary

Alberto Dominguez-Rodriguez, MD, PhD

Role: primary

Alberto Dominguez-Rodriguez, MD, PhD

Role: primary

Other Identifiers

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ARTERIA-2012

Identifier Type: OTHER

Identifier Source: secondary_id

ARTERIA-2012

Identifier Type: -

Identifier Source: org_study_id