Brain Function and Perfusion in Patients With Heart Failure
NCT ID: NCT01756014
Last Updated: 2012-12-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
45 participants
OBSERVATIONAL
2012-01-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Controls
Age matched healthy subjects
No interventions assigned to this group
Mild DCM
Heart failure patients with dilated cardiomyopathy (DCM) with NYHA-functional class II
No interventions assigned to this group
Severe DCM
Heart failure patients with dilated cardiomyopathy (DCM) with NYHA-functional class III/IV
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Age matched with patient group
* Heart failure due to DCM
* 15 patients with NYHA class II
* 15 patients with NYHA class III/IV
Exclusion Criteria
* Carotid artery or intracranial disease, as assessed by echo-doppler (significant stenosis \> 50%)
* Unable or unwilling to undergo MRI
* The presence of ferromagnetic material in or on the body, for example tattoos with ferrous ink or pacemakers or cardiac defibrillators. Also the presence of pregnancy and claustrophobia.
* History of cognitive impairment
* Unable to understand procedures
* Unable or unwilling to provide informed consent
* Age \< 18 years
* History of myocardial infarction
* History of peripheral artery disease
* History of cerebrovascular disease or
* Carotid artery or intracranial disease, as assessed by echo-doppler (significant stenosis \> 50%)
* History of cognitive impairment
* Unable to undergo MRI (eg pacemaker)
* Unable to understand procedures
* Unable or unwilling to provide informed consent
18 Years
ALL
Yes
Sponsors
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University Medical Center Groningen
OTHER
Responsible Party
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A.A.Voors
Prof. dr.
Locations
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University Medical Centre Groningen
Groningen, Provincie Groningen, Netherlands
Countries
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Central Contacts
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Facility Contacts
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Adriaan A Voors, MD/PhD
Role: primary
References
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Erkelens CD, van der Wal HH, de Jong BM, Elting JW, Renken R, Gerritsen M, van Laar PJ, van Deursen VM, van der Meer P, van Veldhuisen DJ, Voors AA, Luijckx GJ. Dynamics of cerebral blood flow in patients with mild non-ischaemic heart failure. Eur J Heart Fail. 2017 Feb;19(2):261-268. doi: 10.1002/ejhf.660. Epub 2016 Nov 14.
Other Identifiers
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BRAIN-HF
Identifier Type: -
Identifier Source: org_study_id