Compare the Knob-tipped Knife With the Needle Knife in Difficult Biliary Cannulation

NCT ID: NCT01745978

Last Updated: 2012-12-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE3

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-12-31

Study Completion Date

2014-12-31

Brief Summary

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The aim of the present study was to compare the efficacy and safety of the knob-tipped knife and needle knife for precut papillotomy in difficult common bile duct (CBD)cannulation.

Detailed Description

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Precut sphincterotomy is an alternative technique used to facilitate CBD cannulation following the failure of conventional bile duct cannulation. Needle knife papillotomy is the most widely practiced precut technique. However,Pre-cutting the papilla with a needle-knife is difficult, requiring experience and dexterity to control the axis and depth of the cut. Due to the increased rate of complications associated with this procedure, including pancreatitis, hemorrhage, and perforation, it was recommended to be performed only by experienced endoscopists.

The knob-tipped knife, a novel instrument utilizing a 2mm or 1.5mm cutting knife, is usually used for endoscopic submucosal dissection (ESD). Its knob-shaped tip and nonadjustable length make the knife less likely to slip and penetrate the tissue during the resection. Since the process of precut papillotomy is similar to ESD, the precutting procedure with the knob-tipped knife may be easier to be performed, as well as be safer. The efficacy and safety of this instrument in precut papillotomy have not been reported. We therefore assessed the efficacy and safety of the knob-tipped knife in precut papillotomy in difficult CBD cannulation.

Conditions

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Endoscopic Retrograde Cholangiopancreatography Bile Duct Diseases

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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the knob-tipped knife

the knob-tipped knife using for precut papillotomy in difficult CBD cannulation

Group Type EXPERIMENTAL

Precut papillotomy

Intervention Type PROCEDURE

the needle knife

the needle knife using for precut papillotomy in difficult CBD cannulation

Group Type ACTIVE_COMPARATOR

Precut papillotomy

Intervention Type PROCEDURE

Interventions

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Precut papillotomy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* intact papilla and deep cannulation of the bile duct
* a standard wire-guided cannulation \>10 minutes, OR Pancreatic contrast injections ≥3, OR Pancreatic deep wire pass ≥5

Exclusion Criteria

* ampullary tumors
* Billroth II or Roux-en-Y anatomy
* prior endoscopic sphincterotomy(EST) or biliary stent
* choledochoduodenal fistulae
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Changhai Hospital

OTHER

Sponsor Role lead

Responsible Party

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Zhaoshen Li

Director of Gastroenterology

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Changhai Hospital, Second Military Medical University

Shanghai, , China

Site Status RECRUITING

Countries

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China

Central Contacts

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zhaoshen Li, MD

Role: CONTACT

Phone: 86-21-81873241

Email: [email protected]

feng Liu, MD

Role: CONTACT

Phone: 86-21-81873262

Email: [email protected]

Facility Contacts

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zhaoshen Li, MD

Role: primary

Other Identifiers

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changhai-121202

Identifier Type: -

Identifier Source: org_study_id