Can Thrombin Generation Measurement Predict the Risk of Venous Thromboembolism in Acute Ill Patients
NCT ID: NCT01744431
Last Updated: 2015-12-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
400 participants
OBSERVATIONAL
2012-12-31
2013-09-30
Brief Summary
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Traditional coagulation tests do not assess the whole coagulation system. Thrombin generation assays measure the ability of plasma sample to generate thrombin following in vitro activation of coagulation. In contrast to the classical clotting assays, thrombin generation reflects and integrates all pro and anticoagulant reactions that regulate the formation and inhibition of thrombin.
The aim of our study is to investigate whether thrombin generation would be able to predict a hypercoagulable state in acute ill patients admitted in the internal medical departments and how it correlates with the Padua prediction score, a score that could assists the risk for venous thromboembolism in hospitalized medical patients.
In total 300 patients are planned for inclusion in this trial. After signing an informed consent a blood sample will be obtained from each participant. We will measure the thrombin generation over time in plasma assessed by the calibrated automated thrombogram (CAT).
Detailed Description
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Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Study Groups
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No treatment
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
ALL
No
Sponsors
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HaEmek Medical Center, Israel
OTHER
Responsible Party
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Elias mazen
Director of Internal Medicine
Principal Investigators
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mazen elias, MD
Role: PRINCIPAL_INVESTIGATOR
Emek Medical Center
Locations
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Emek medical center
Afula, , Israel
Countries
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Other Identifiers
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thrombin generation
Identifier Type: -
Identifier Source: org_study_id