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Bioavailability of Chemopreventive and Nutritional Compounds in Broccoli

NCT ID: NCT01743924

Last Updated: 2012-12-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

EARLY_PHASE1

Total Enrollment

7 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-07-31

Study Completion Date

2011-07-31

Brief Summary

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The aim of this study was to determine the absorption of isothiocyanates (ITC) after ingestion of kailan-hybrid broccoli through the analysis of the correspondent urinary biomarkers. Furthermore, the effect of cooking (microwave) on the mentioned metabolic fate of these ITC was studied comparing to the uncooked vegetable.

Detailed Description

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Background Glucosinolates (sulphur-containing compounds) are hydrolyzed by the plant enzyme myrosinase to ITC, which have chemopreventive properties. No information has been reported about the metabolic fate of ITC in the kailan-hybrid broccoli, which physicochemical characteristics could greatly influence that metabolic fate. Previous studies have shown that cooking process of vegetables may vary the human absorption of the correspondent nutritional and bioactive compounds.

Research Methods \& Procedures A cross-over-design study of 7 subjects after ingestion of 200-g raw or microwaved kailan-hybrid broccoli was conducted. Total ITC equivalents in the vegetable, urine and blood samples were determined by HPLC as the cyclocondensation product of 1,2-benzenedithiol.

Conditions

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Bioavailability

Keywords

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Broccoli; Isothiocyanates; Pharmacokinetics; Sulforaphane; Myrosinase

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

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Raw

Broccoli,200 grams

Group Type EXPERIMENTAL

raw broccoli

Intervention Type OTHER

To eat this plant material

cooked

Microwaved, 200 grams

Group Type EXPERIMENTAL

raw broccoli

Intervention Type OTHER

To eat this plant material

Interventions

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raw broccoli

To eat this plant material

Intervention Type OTHER

Other Intervention Names

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Bimi Kailan hybrid

Eligibility Criteria

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Inclusion Criteria

* Subjects with a body mass index between 19 and 28.
* Subjects age: 22-50 years-old.
* Good health of subjects: confirmed by medical history, physical examination and clinical laboratory analysis of urine and blood (complete blood count and liver function markers including serum glutamic-pyruvic transaminase bilirubin test and glucose-6-phosphate dehydrogenase).

Exclusion Criteria

* Tobacco smoking.
* Use of regular medications.
* Had taken antibiotics for 4 weeks immediately preceding the study.
* History of kidney stones, diabetes mellitus, bleeding disorders or family history of iron overload/hemochromatosis.
Minimum Eligible Age

22 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hospital Universitario Reina Sofia de Cordoba

OTHER_GOV

Sponsor Role collaborator

Universidad Politécnica de Cartagena

OTHER

Sponsor Role lead

Responsible Party

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Ginés Benito Martínez Hernández

Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Maria Concepcion Maeztu Sardiña, Doctor

Role: STUDY_CHAIR

Comité ético de investigación clínica

Locations

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Hospital General Universitario Reina Sofía

Murcia, Murcia, Spain

Site Status

Countries

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Spain

Other Identifiers

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Broccoli_Bioav.

Identifier Type: -

Identifier Source: org_study_id