Ultrasound Guided Transversus Abdominis Plane Block With Ropivacaine vs Placebo for Abdominal Hysterectomy: a Double-blinded, Randomized Clinical Trial

NCT ID: NCT01743378

Last Updated: 2013-08-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-02-28

Study Completion Date

2013-06-30

Brief Summary

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A Prospective double-blinded randomized clinical trial to test the effect of transversus abdominis plane block on postoperative pain and opoid consumption after abdominal hysterectomy.

Two groups of each 24 patients. All patients are given general anesthesia. The patients are randomized to have a ultrasound guided bilateral transversus abdominis plane block with either 2 x 20 ml 0,75 % ropivacaine or 2 x 20 ml of 0,9 saline. All patients are provided with a PCA for self administration of morphine.

Pain score on visual analog scale, nausea and vomiting are monitored at 1, 2, 4, 6, 8 and 24 hours postoperatively as well as the total consumption of morphine after 24 hours.

Detailed Description

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Conditions

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Postoperative Pain and Postoperative Morphine Consumption After Abdominal Hysterectomy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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TAP Block Ropivacaine 0,75 %

Bilateral Transversus Abdominis Plane Block with 2 x 20 ml Ropivacaine 0,75 %

Group Type EXPERIMENTAL

TAP Block Ropivacaine 0,75 %

Intervention Type PROCEDURE

TAP Block Saline 0,9 %

Bilateral Transversus abdominis plane block with 2 x 20 ml Saline 0,9 %

Group Type PLACEBO_COMPARATOR

TAP Block Saline 0,9 %

Intervention Type PROCEDURE

Interventions

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TAP Block Ropivacaine 0,75 %

Intervention Type PROCEDURE

TAP Block Saline 0,9 %

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Assigned to elective abdominal hysterectomy
* Must be able to understand and speak danish
* Must be able to give verbal and written consent

Exclusion Criteria

* Abuse of alcohol or medicin
* Daily treatment with opoids or glucocorticoids
* Allergy towards any kind of localanesthetic drug
* Intolerance toward morphine
* Psychiatric desease
* Age below 18
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Hvidovre University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Billy B Kristensen

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Hvidovre Hospital

Hvidovre, Capital Region, Denmark

Site Status

Countries

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Denmark

Other Identifiers

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H-1-2010-068

Identifier Type: -

Identifier Source: org_study_id