Nutritional Risk Factors for Hip Fracture: a Case Control Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

184 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-09-30

Study Completion Date

2011-04-30

Brief Summary

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Low Body Mass Index (BMI) is a risk factor for hip fracture, but it is unknown if it is the low BMI per se that increases risk of hip fracture or if specific micro-nutrients contribute. The investigators want to elucidate this aspect in a case control study studying micronutrients in serum and bone turnover markers of hip fracture patients compared with controls of the same age.

Detailed Description

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Conditions

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Hip Fracture

Keywords

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hip fracture risk factors vitamin K1 vitamin D bone turnover markers osteocalcin undercarboxylated osteocalcin bone specific alkaline phosphatase (BALP) insulin like growth factor 1 (IGF1) parathyroid hormone (PTH)

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Cases

Hip fracture patients participating in a randomised controlled trial (RCT) of orthogeriatric care (ClinicalTrials.gov NCT01009268)

No interventions assigned to this group

Controls

A group of voluntary elderly persons without a history of hip fracture, recruited specifically for this purpose

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

Cases are admitted acutely for a femoral neck fracture, a trochanteric or a subtrochanteric femoral fracture.

Exclusion Criteria

* Hip fracture as part of multi-trauma or high energy trauma (defined as a fall from a higher level than 1 metre). One recent fracture in addition to the hip fracture (e.g. radius or shoulder) is acceptable.
* Regarded as moribund at admittance.
* Absence of a valid informed consent or assent.

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Anne Torbergsen

Clinical Nutritionist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Morten Mowe, PhD

Role: STUDY_CHAIR

Oslo University Hospital

Locations

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University of Oslo, Institute of Clinical Medicine

Oslo, , Norway

Site Status

Countries

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Norway

References

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Torbergsen AC, Watne LO, Frihagen F, Wyller TB, Mowe M. Effects of nutritional intervention upon bone turnover in elderly hip fracture patients. Randomized controlled trial. Clin Nutr ESPEN. 2019 Feb;29:52-58. doi: 10.1016/j.clnesp.2017.11.012. Epub 2018 Oct 30.

Reference Type DERIVED

PMID: 30661701 (View on PubMed)

Torbergsen AC, Watne LO, Wyller TB, Frihagen F, Stromsoe K, Bohmer T, Mowe M. Micronutrients and the risk of hip fracture: Case-control study. Clin Nutr. 2017 Apr;36(2):438-443. doi: 10.1016/j.clnu.2015.12.014. Epub 2015 Dec 23.