Ultrasonic Explorations of Cerebral Tissue Motions - Influence of Aging
NCT ID: NCT01737606
Last Updated: 2013-09-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
53 participants
INTERVENTIONAL
2012-09-30
2013-07-31
Brief Summary
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Detailed Description
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Phase 1:
-Study the in-vivo development of ultrasonic method in terms of quality of the acquisitions and intra-operator reproducibility.
Study the ease of positioning in relation to MRI and fusion of MRI and FCPI data via the neuro-navigation system
Phase 2:
-Study the variability of cerebral pulsatility of measured by "Fast Cerebral Pulsatility Imaging" or FCPI with age.
Secondary objectives
* Compare the results of displacements cartography's and vascular cartography obtained by MRI (especially by Arteriel Spin Labelling = ASL)
* Compare results of FCPI with results of cognitive tests of aging separating fluid functions (prefrontal) and functions called crystallized; and study the residual effect of age on cognitive tasks and speed of cognitive processing after taking into account the effect of the cerebral pulsatility
* Compare results of FCPI with electrophysiological measures (PE EEG) describing the attentional control
* Perform an exploratory analysis to highlight the propagating part of the brain displacement maps
Conditions
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Keywords
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Study Design
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NA
SINGLE_GROUP
HEALTH_SERVICES_RESEARCH
NONE
Study Groups
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echography
Fast Cerebral Pulsatility Imaging
Fast Cerebral Pulsatility Imaging
Cerebral ultrasonic exploration using with neuro-navigation system : 4 acquisitions on 12 or 6 section planes
Interventions
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Fast Cerebral Pulsatility Imaging
Cerebral ultrasonic exploration using with neuro-navigation system : 4 acquisitions on 12 or 6 section planes
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Informed consent form signed
* Person affiliated to a medical insurance
* Male or female
* No smoking the day of the inclusion
* Right handed: Edinburgh test ≥0.8 (subjects of phase 2)
* MMS score ≥ 27 and 5 words score = 10 (subjects of phase 2)
* Socio-educational level greater than or equal to 8 years of school (subjects of phase 2)
Exclusion Criteria
* Contraindications to IRM for patients with: ocular metallic foreign object; any electronic medical device implanted by irremovable way (pacemakers, neuro-stimulator, cochlear implants ...); metallic heart valve, old heart valves are specially an absolute contraindication because of risk of dysfunction; vascular clips implanted formerly on brain aneurysm
* Acute medico-surgical condition dating from less than 3 months
* Neurological and neuro-surgical pathology such as: toxic, infectious or inflammatory encephalopathy, epilepsy, intracranial arteriovenous malformation known, intracranial tumor or hydrocephalus known, operated or no, history of ischemic or hemorrhagic stroke, transient or not
* Treatments or pathology that could influence the results of the research: heart failure (dyspnea with stage III or IV NYHA) or non-sinus cardiac rhythm, use of central analgesics or psychotropic drugs
* Psychiatrics disorders of axe 1 of DSM IV, based on MINI (subjects of phase 2)
* Major subject with a legal protection measure
* Subject to exclusion period of any other biomedical research
18 Years
ALL
Yes
Sponsors
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University Hospital, Tours
OTHER
Responsible Party
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Principal Investigators
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Frédéric PATAT, MD
Role: PRINCIPAL_INVESTIGATOR
University Hospital of Tours
Locations
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University Hospital of Tours
Tours, , France
Countries
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Other Identifiers
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PHAO 2012 - FP / COSTUM
Identifier Type: -
Identifier Source: org_study_id