Prostate Cancer Active Surveillance Metformin Trial

NCT ID: NCT01733836

Last Updated: 2013-05-24

Basic Information

• Recruitment Status: WITHDRAWN
• Clinical Phase: PHASE2
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-01-31
• Study Completion Date: 2014-10-31

Brief Summary

To determine whether the use of metformin in patients with low-risk prostate cancer can delay progression to clinically significant prostate cancer.

Conditions

Prostate Cancer

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Metformin

850mg BID

Group Type: EXPERIMENTAL

Metformin

Intervention Type: DRUG

Placebo

Group Type: PLACEBO_COMPARATOR

placebo

Intervention Type: DRUG

Interventions

Metformin

Intervention Type: DRUG

placebo

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Willing and able to provide informed consent
• Men >= 18 years of age, and less than 80
• Men with biopsy proven, low-risk, localized prostate cancer (as defined below)
• Men choosing expectant management as primary treatment for prostate cancer
• Diagnostic biopsy performed within 4 months of screening visit
• Gleason score ≤ 6 in 3 cores or less with no Gleason pattern 4, less than 50% of any core involved in cancer
• Clinical stage T1c-T2a (Initial diagnosis of T1a/T1b obtained during a TURP is not allowed)
• Serum PSA ≤10 ng/mL
• Life expectancy greater than 5 years
• Normal kidney and hepatic function as defined by the following criteria:

• Total bilirubin less than 1.5 X institutional upper limit of normal (ULN)
• AST (SGOT)/ALT(SGPT) less than 1.5 X institutional ULN
• Alkaline phosphatase less than 2 X institutional ULN
• Creatinine less than 1.4 X institutional ULN
• Able to swallow and retain oral medication
• No exposure to metformin within 12 months of randomization
• No known hypersensitivity or intolerance to metformin hydrochloride
• No condition associated with increased risk of metformin hydrochloride-associated lactic acidosis (e.g., congestive heart failure defined as NYHA class III or IV function status, history of acidosis of any type, or habitual intake of ≥ 3 alcoholic beverages per day, or age greater than 80)
• English fluency allowing for patient reported outcomes completion

Exclusion Criteria

• Any previous prostate cancer treatment (radiotherapy, chemotherapy, hormonal therapy, oral glucocorticoids, GnRH analogues)
• Diabetes including type 1 diabetes. Patients with known type 2 diabetes are eligible provided they have not been on metformin during the previous 12 months and are not on any other pharmacological agents.
• Concurrent or previous use of anabolic steroids or drugs with anti androgenic properties including 5-ARIs (dutasteride and finasteride)
• Prostate volume greater than 80 cc. (as per TRUS biopsy report)
• Prostatic surgery or procedure within 3 months of screening visit
• Severe BPH symptoms (IPSS ≥25, or ≥20 if already on α-blocker therapy)
• Other malignancies, with the exception of adequately treated nonmelanoma skin cancer, NMIBC or other solid tumors curatively treated with no evidence of disease for ≥ 5 years
• Planned or concurrent participation in other interventional randomized trials including exercise
• The presence of any other coexistent medical condition that in the opinion of the investigator would have the potential to significantly limit adherence to medication, or ability to absorb the medication including but not limited to psychiatric conditions, malabsorption syndromes or severe ischemic heart disease
• Known hypersensitivity or intolerance to metformin
• Concurrent or planned participation in randomized trials of weight loss or exercise interventions or trials targeting insulin, IGF-1 or their receptors, or PI3K inhibitors.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: No

Sponsors

University Health Network, Toronto

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

University Health Network

Toronto, Ontario, Canada

Countries

Canada

References

Roy S, Malone S, Grimes S, Morgan SC. Impact of Concomitant Medications on Biochemical Outcome in Localised Prostate Cancer Treated with Radiotherapy and Androgen Deprivation Therapy. Clin Oncol (R Coll Radiol). 2021 Mar;33(3):181-190. doi: 10.1016/j.clon.2020.09.005. Epub 2020 Sep 29.

Reference Type: DERIVED

PMID: 32994091 (View on PubMed)

Other Identifiers

MAS_001

Identifier Type: -

Identifier Source: org_study_id