FungiScope - A Global Emerging Fungal Infection Registry

NCT ID: NCT01731353

Last Updated: 2023-12-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2003-03-31

Study Completion Date

2026-12-31

Brief Summary

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The objective of this registry is to broaden the knowledge on epidemiology, diagnostic procedures and clinical course of emerging invasive fungal infections.

Detailed Description

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The specific objectives are:

1. To determine the fungal species causing invasive fungal infection in different parts of the world.
2. To determine the clinical pattern of disease and document procedures performed for confirmation of the diagnosis.
3. To describe the therapeutic regimens used and their efficacy.
4. To share clinical isolates among the contributors of Fungiscope.
5. To develop molecular biology tools for identification of strains in histopathologically proven invasive fungal infection.

Conditions

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Invasive Fungal Disease

Keywords

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invasive fungal infection Web-based registry

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Emerging fungal infections

Web-based registry of invasive infections by emerging fungi

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Cultural, histopathological, antigen or DNA evidence of invasive fungal infection

Exclusion Criteria

* Infection due to Candida spp., Cryptococcus neoformans, Pneumocystis jiroveci
* Endemic fungal infection such as coccidioidomycosis or histoplasmosis
* Colonisation or other non-invasive infection
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role collaborator

Basilea Pharmaceutica

INDUSTRY

Sponsor Role collaborator

Cidara Therapeutics Inc.

INDUSTRY

Sponsor Role collaborator

F2G Biotech GmbH

INDUSTRY

Sponsor Role collaborator

Matinas Biopharma, Inc

INDUSTRY

Sponsor Role collaborator

University of Cologne

OTHER

Sponsor Role lead

Responsible Party

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Oliver Cornely, MD

Dr. med.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Oliver A. Cornely, Professor

Role: PRINCIPAL_INVESTIGATOR

University Hospital of Cologne

Locations

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University Hospital Cologne

Cologne, North Rhine-Westphalia, Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Oliver A Cornely, Prof.

Role: CONTACT

Phone: +49 221 478

Email: [email protected]

Facility Contacts

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Oliver A Cornely, Prof.

Role: primary

Danila Seidel, PhD

Role: backup

References

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Koehler P, von Stillfried S, Garcia Borrega J, Fuchs F, Salmanton-Garcia J, Pult F, Boll B, Eichenauer DA, Shimabukuro-Vornhagen A, Kurzai O, Boor P, Kochanek M, Cornely OA. Aspergillus tracheobronchitis in COVID-19 patients with acute respiratory distress syndrome: a cohort study. Eur Respir J. 2022 May 5;59(5):2103142. doi: 10.1183/13993003.03142-2021. Print 2022 May.

Reference Type DERIVED
PMID: 35144992 (View on PubMed)

Hassler A, Lieb A, Seidel D, Cesaro S, Greil J, Klimko N, Khostelidi S, Solopova G, Ogunc D, Duran Graeff L, Cornely OA, Vehreschild MJ, Lehrnbecher T. Disseminated Fusariosis in Immunocompromised Children-Analysis of Recent Cases Identified in the Global Fungiscope Registry. Pediatr Infect Dis J. 2017 Feb;36(2):230-231. doi: 10.1097/INF.0000000000001396.

Reference Type DERIVED
PMID: 27846057 (View on PubMed)

Marty FM, Ostrosky-Zeichner L, Cornely OA, Mullane KM, Perfect JR, Thompson GR 3rd, Alangaden GJ, Brown JM, Fredricks DN, Heinz WJ, Herbrecht R, Klimko N, Klyasova G, Maertens JA, Melinkeri SR, Oren I, Pappas PG, Racil Z, Rahav G, Santos R, Schwartz S, Vehreschild JJ, Young JH, Chetchotisakd P, Jaruratanasirikul S, Kanj SS, Engelhardt M, Kaufhold A, Ito M, Lee M, Sasse C, Maher RM, Zeiher B, Vehreschild MJGT; VITAL and FungiScope Mucormycosis Investigators. Isavuconazole treatment for mucormycosis: a single-arm open-label trial and case-control analysis. Lancet Infect Dis. 2016 Jul;16(7):828-837. doi: 10.1016/S1473-3099(16)00071-2. Epub 2016 Mar 9.

Reference Type DERIVED
PMID: 26969258 (View on PubMed)

Related Links

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http://www.fungiscope.net

FungiScope - A Global Emerging Fungal Infection Registry

http://fungiquest.net/

FungiQuest - Search Engine for rare fungal infection

Other Identifiers

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Fungi001

Identifier Type: -

Identifier Source: org_study_id