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Preliminary Study of Sonic Hedgehog Signaling Pathway in the Pathogenesis of Rheumatoid Arthritis

NCT ID: NCT01731262

Last Updated: 2012-11-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

78 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-11-30

Study Completion Date

2013-01-31

Brief Summary

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Rheumatoid arthritis(RA) with a high incidence and high morbidity, the pathogenesis has not been fully elucidated. Fibroblast-like synovial cells excessive proliferation and synovial angiogenesis is the most important cause of RA synovitis and joint destruction. Our study was to find the role of Sonic Hedgehog(SHH) pathway in regulating proliferation of fibroblast-like synovial cells and modulating excess angiogenesis of synovial tissue.

Detailed Description

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4ml blood from active RA patients(n=35) and healthy volunteers (n=35) will be collected

* peripheral blood mononuclear cells will be detached
* messenger ribonucleic acid expression of Sonic Hedgehog pathway associated factors in both groups will be detected

Synovial tissues from 4 RA patients and 4 patients with traumatic or meniscal injury who need to carry out knee joint replacement operation will be collected

* inflammatory feature of synovial tissue will be observed
* the expression of Shh, Ptch1, Gli1 and Smo in synovial tissue will be detected by immunohistochemistry assay
* fibroblast-like synoviocytes will be cultured from synovial tissue of RA patients

Conditions

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Arthritis, Rheumatoid Neovascularization, Pathologic Synovitis

Keywords

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Arthritis, Rheumatoid Sonic hedgehog protein, human Neovascularization, Pathologic Synovitis

Study Design

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Observational Model Type

CASE_CONTROL

Study Groups

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RA group

expression of Shh pathway associated factors from peripheral blood mononuclear cells or synovial tissues will be detected

No interventions assigned to this group

control group

expression of Shh pathway associated factors from peripheral blood mononuclear cells or synovial tissues will be detected

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* definitely diagnosed
* the disease is active (DAS28\>3.2)

Exclusion Criteria

* combined with severe organ dysfunction
* combined with other rheumatic diseases
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Natural Science Foundation of China

OTHER_GOV

Sponsor Role collaborator

Third Affiliated Hospital, Sun Yat-Sen University

OTHER

Sponsor Role lead

Responsible Party

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Shangling Zhu

Post-Graduate

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jianlin Huang, PhD

Role: PRINCIPAL_INVESTIGATOR

Third Affiliated Hospital, Sun Yat-Sen University

Central Contacts

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Jianlin Huang, PhD

Role: CONTACT

Phone: 86 02085252194

Email: [email protected]

Guihua Chen, PhD

Role: CONTACT

Phone: 86 02085252205

Email: [email protected]

Other Identifiers

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中大附三医伦[2012]2-75号

Identifier Type: -

Identifier Source: org_study_id