Study of REGN1400 Alone and in Combination With Erlotinib or Cetuximab in Patients With Certain Types of Cancer
NCT01727869 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 56
Last updated 2015-04-06
Summary
This is an open-label, multicenter, ascending multiple dose study of REGN1400 alone and in combination with erlotinib or cetuximab administered to patients with certain types of cancer.
Conditions
- Cancer
Interventions
- DRUG
-
REGN1400
- DRUG
-
Erlotinib
- DRUG
-
Cetuximab
Sponsors & Collaborators
-
Regeneron Pharmaceuticals
lead INDUSTRY
Principal Investigators
-
Clinical Trial Management · Regeneron Pharmaceuticals
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2012-10-31
- Primary Completion
- 2015-01-31
- Completion
- 2015-01-31
Countries
- United States
Study Locations
Related Clinical Trials
-
Study of CGC-11047 When Used in Individual Combinations With 1) Gemcitabine or 2) Docetaxel or 3) Bevacizumab or 4) Erlotinib or 5) Cisplatin or 6) 5-Flurouracil or 7) Sunitinib in Patients With Advanced Solid Tumors or Lymphoma
NCT00705874 · Status: COMPLETED · Phase: PHASE1
- Cancer
-
Activity of Regorafenib in Combination With Chemotherapy in Patients With Advanced Biliary Tract Cancer
NCT02386397 · Status: COMPLETED · Phase: PHASE1/PHASE2
- Digestive Cancer
-
Regorafenib Versus Placebo to Treat Cholangiocarcinoma
NCT02162914 · Status: UNKNOWN · Phase: PHASE2
- Cholangiocarcinoma
-
Capecitabine/Oxaliplatin Chemotherapy and Cemiplimab With or Without Fianlimab or REGN7075 in Locally Advanced Rectal Cancer
NCT07281768 · Status: NOT_YET_RECRUITING · Phase: PHASE2
- Colorectal Cancer
-
Oxaliplatin, Gemcitabine, Erlotinib, and Radiation Therapy in Treating Patients With Unresectable and/or Metastatic Pancreatic Cancer or Biliary Tract Cancer
NCT00266097 · Status: COMPLETED · Phase: PHASE1
- Extrahepatic Bile Duct Cancer
- Gallbladder Cancer
- Pancreatic Cancer
More Related Trials
-
PF-04856884 (CVX-060) In Combination With Axitinib In Patients With Previously Treated Metastatic Renal Cell Carcinoma
NCT01441414 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of Aflibercept Administered in Combination With Pemetrexed and Cisplatin in Participants With Advanced Carcinoma
NCT00794417 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Cisplatin and Gemcitabine Plus Trastuzumab in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer
NCT00016367 ·Status: COMPLETED ·Phase: PHASE2
-
Study Of OX40 Agonist PF-04518600 Alone And In Combination With 4-1BB Agonist PF-05082566
NCT02315066 ·Status: COMPLETED ·Phase: PHASE1
-
Determination of Safety, Efficacy, and Pharmacokinetics of "Regorafenib" Combined With Pemetrexed and Cisplatin in Patients With Nonsquamous Non-Small Cell Lung Cancer
NCT01187615 ·Status: TERMINATED ·Phase: PHASE1
-
Gemcitabine, Oxaliplatin in Combination With Bevacizumab in Patients With Hepatocellular Carcinoma
NCT00142467 ·Status: COMPLETED ·Phase: PHASE2
-
Study of AR-67 (Formerly DB-67) in Adult Patients With Refractory or Metastatic Solid Malignancies
NCT00389480 ·Status: COMPLETED ·Phase: PHASE1
-
Cilengitide and Cetuximab in Combination With Platinum-based Chemotherapy as First-line Treatment for Subjects With Advanced Non Small Cell Lung Cancer (NSCLC)
NCT00842712 ·Status: COMPLETED ·Phase: PHASE2
-
Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer
NCT00397384 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of RO6927005 Either As Monotherapy (Part A) or in Combination With Gemcitabine and Nab-Paclitaxel (Part B) to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Clinical Activity in Patients With Mesothelin-positive Metastatic and/or Locally Advanced Malignant Solid Tumors
NCT02317419 ·Status: TERMINATED ·Phase: PHASE1
-
Bortezomib and Cetuximab in Treating Patients With Advanced Solid Tumors
NCT00622674 ·Status: COMPLETED ·Phase: PHASE1
-
Biliary Cancers: EGFR INhibitor, Gemcitabine and Oxaliplatin
NCT00552149 ·Status: COMPLETED ·Phase: PHASE2
-
Cetuximab, Gemcitabine, and Oxaliplatin in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer
NCT00448838 ·Status: COMPLETED ·Phase: NA
-
Study Of CP-751,871 In Combination With Cisplatin And Gemcitabine In Chemotherapy-Naïve Patients With Advanced Non-Small Cell Lung Cancer
NCT00560573 ·Status: COMPLETED ·Phase: PHASE1
-
Capecitabine, Irinotecan, and Oxaliplatin in Treating Patients With Metastatic Cancer
NCT00544063 ·Status: UNKNOWN ·Phase: PHASE1
-
A Study of the Efficacy of Cannabidiol in Patients With Multiple Myeloma, Glioblastoma Multiforme, and GI Malignancies
NCT03607643 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Oxaliplatin Plus Capecitabine in Treating Patients With Metastatic or Recurrent Solid Tumor
NCT00005839 ·Status: COMPLETED ·Phase: PHASE1
-
Oxaliplatin and Irinotecan in Recurrent or Metastatic Esophageal and Gastroesophageal (GE) Junction Carcinoma
NCT00256269 ·Status: TERMINATED ·Phase: PHASE2
-
A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.
NCT06447662 ·Status: RECRUITING ·Phase: PHASE1
-
Phase I/II Study of Lapatinib in Combination With Oxaliplatin and Capecitabine in Subjects With Advanced Colorectal Cancer
NCT00536809 ·Status: COMPLETED ·Phase: PHASE1
-
Surgery, Gemcitabine, Cisplatin, and Radiation Therapy in Treating Patients With Stage II or Stage III Non-Small Cell Lung Cancer
NCT00530634 ·Status: TERMINATED ·Phase: PHASE2
-
Gemcitabine in Treating Patients With Recurrent or Refractory Bladder Cancer
NCT00014287 ·Status: WITHDRAWN ·Phase: PHASE1
-
Phase II Trial of Oxaliplatin in Combination With S-1(SOX) in Patients With Recurrent or Metastatic Breast Cancer
NCT00527930 ·Status: COMPLETED ·Phase: PHASE2
-
Oxaliplatin and Capecitabine in the Treatment of Relapsed/Refractory Carcinoma of Unknown Primary Site
NCT00193609 ·Status: COMPLETED ·Phase: PHASE2
-
Capecitabine, Oxaliplatin, Bevacizumab and Radiation Therapy in Patients With Biliary Tract and Gallbladder Cancer
NCT00142480 ·Status: COMPLETED ·Phase: PHASE2