Trial Outcomes & Findings for CO as a Stimulant for Mitochondrial Biogenesis in Human Cardiac Muscle (NCT NCT01727167)
NCT ID: NCT01727167
Last Updated: 2016-05-19
Results Overview
Right atrial biochemical markers will be measured one time only, intra-operatively. Blood Biochemical markers will be measured before CO exposure and at intervals up to one week post-operatively
TERMINATED
PHASE1/PHASE2
1 participants
2 weeks
2016-05-19
Participant Flow
Participant milestones
| Measure |
Control Group
This group will breath room air for one hour per day over the course of the three days immediately prior to surgery.
Control: This group will breath room air for one hour per day over the course of the three days immediately prior to surgery.
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CO Group
This group will breath 200 ppm of CO for one hour per day over the course of the three days immediately prior to surgery.
200ppm CO for one hour: This is the study intervention. The treatment group will breath 200 ppm of CO for one hour over the three days immediately prior to surgery.
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Overall Study
STARTED
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1
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0
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Overall Study
COMPLETED
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1
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0
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Overall Study
NOT COMPLETED
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0
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0
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Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
CO as a Stimulant for Mitochondrial Biogenesis in Human Cardiac Muscle
Baseline characteristics by cohort
Baseline data not reported
PRIMARY outcome
Timeframe: 2 weeksPopulation: Molecular data was not collected for the single enrolled participant.
Right atrial biochemical markers will be measured one time only, intra-operatively. Blood Biochemical markers will be measured before CO exposure and at intervals up to one week post-operatively
Outcome measures
Outcome data not reported
SECONDARY outcome
Timeframe: on weekPopulation: Molecular data was not collected for the single enrolled participant.
Biochemical markers in both right atrial tissue and blood will be measured and compared to see if the more easily obtained blood markers accurately describe changes expected in the heart.
Outcome measures
Outcome data not reported
Adverse Events
Control Group
CO Group
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
John J. Freiberger, M.D.
Duke University Medical Center
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place