Does First Oral Intake After Emergence Predict the Incidence of Post-operative Vomiting in Children?

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

183 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-10-31

Study Completion Date

2013-12-31

Brief Summary

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Second only to pain, nausea and vomiting are the most uncomfortable complications of surgery and anesthesia. Unfortunately, our best defense against post-operative nausea and vomiting, a medicine called ondansetron (Zofran), is in dire national shortage. Consequently, non-pharmacological methods of prevention and treatment for post-operative nausea and vomiting have increased import. Following emergence from general anesthesia, children often request food and drink. There have been no studies to date that definitively determine the optimal first food or drink choice for these children. This study proposes to randomize children to either water or juice first intake following surgery. The investigators expect to find that children who consume glucose are less likely to vomit than those who first receive water.

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Detailed Description

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Conditions

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Post-operative Vomiting

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Caregivers Outcome Assessors

Study Groups

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Water

Water will be given as the study subject's first oral intake after emergence from general anesthesia.

Group Type PLACEBO_COMPARATOR

Water

Intervention Type OTHER

Apple Juice

Apple juice will be given as the study subject's first oral intake after emergence from general anesthesia.

Group Type EXPERIMENTAL

Apple Juice

Intervention Type OTHER

Interventions

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Apple Juice

Intervention Type OTHER

Water

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Dental surgery
* Tonsillectomy and adenoidectomy
* Strabismus surgery
* Age 2-18

Exclusion Criteria

* Patient refusal
* Parent refusal
* Allergy / contraindication to ondansetron
* Prone to vomiting
* Inpatient
* Preoperative anxiolysis with ketamine
* Recovery location other than PACU
* Nil per os at baseline
* Presence of enteric tube
* Contraindication to any part of the study protocol

Minimum Eligible Age

2 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes