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Neural and Physiological Responses to Real-World Experiences

NCT ID: NCT01723410

Last Updated: 2015-12-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-01-31

Study Completion Date

2015-01-31

Brief Summary

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UCLA researchers looking for healthy individuals (aged 35-50) who have a home computer with internet access, are not pregnant, planning to become pregnant, or currently breastfeeding (if female), to participate in a study investigating whether real-world experiences alter the brain and body. This study takes place over an eight week period and involves providing the names of 8 close friends or family members, completing a neuroimaging session, providing blood and saliva (for genetic analysis), and a 6-week period in which participants login twice a week to complete online questionnaires. Compensation is up to $210 for those who complete all aspects of the study. Please email [email protected] for more information.

Detailed Description

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Conditions

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Gene Expression

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Writing condition

Subjects will be asked to write about other individuals in their lives.

Group Type EXPERIMENTAL

Writing about people

Intervention Type BEHAVIORAL

Subjects will be asked to write about other people in their lives once a week for 6-weeks.

Writing

Subjects will be asked to write about places or objects in their lives.

Group Type PLACEBO_COMPARATOR

Writing about places, objects

Intervention Type OTHER

Interventions

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Writing about people

Subjects will be asked to write about other people in their lives once a week for 6-weeks.

Intervention Type BEHAVIORAL

Writing about places, objects

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy adults between the ages of 35-50

Exclusion Criteria

Following a structured telephone interview, prospective participants with the following conditions will not be able to participate:

1. claustrophobia, left-handedness, or presence of metal in their body (for the neuroimaging procedures),
2. possible presence of a depressive disorder, which may interfere with the gratitude intervention (assessed by the Patient Health Questionnaire; Spitzer et al., 1999),
3. regular use of medications that may impact inflammatory processes (anti-inflammatory drugs, steroids, opioids),
4. current smokers or excessive caffeine users (\> 600 mg/day) because of known effects on inflammation, and
5. pregnancy (which would affect oxytocin gene expression).
Minimum Eligible Age

35 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of California, Los Angeles

OTHER

Sponsor Role lead

Responsible Party

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Naomi Eisenberger

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Naomi I Eisenberger, PhD

Role: PRINCIPAL_INVESTIGATOR

University of California, Los Angeles

Locations

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UCLA CTRC & Brain Mapping Center

Los Angeles, California, United States

Site Status

Countries

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United States

Other Identifiers

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GGSC-GRAT

Identifier Type: -

Identifier Source: org_study_id