Trial Outcomes & Findings for Brain Nicotine Receptor Density in Veteran Smokers (NCT NCT01721473)

Results Overview

Vt/fp values (indicating relative densities of alpha4beta2 nicotinic acetylcholine receptors in different brain regions) in various brain regions - can also be referred to as mL/cm3.

Recruitment status

COMPLETED

Target enrollment

184 participants

Primary outcome timeframe

Primary outcome measures will be determined over approximately 3 weeks

Results posted on

2019-10-07

Participant Flow

Participant milestones

Participant milestones
Measure	Non-smokers People who did not smoke or use heavy caffeine or marijuana	Menthol Smokers People who smoke menthol cigarettes.	Non-menthol Smokers People who smoke non-menthol cigarettes	Smokers Without Comorbidities People who smoke without heavy caffeine or marijuana use.	Smokers With Caffeine People who smoke and have heavy caffeine use.	Smokers With Marijuana People who smoke and heavily use marijuana.
Overall Study STARTED	47	22	41	34	22	18
Overall Study COMPLETED	47	22	41	34	22	18
Overall Study NOT COMPLETED	0	0	0	0	0	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Brain Nicotine Receptor Density in Veteran Smokers

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Non-smokers n=47 Participants People who did not smoke.	Smokers Methol n=22 Participants People who smoke menthol cigarettes.	Smokers Non Menthol n=41 Participants People who smoke non menthol cigarettes.	Smokers Without Comorbidities n=34 Participants People who smoke but do not have heavy caffeine or marijuana use.	Smokers With Caffeine n=22 Participants People who smoke and have heavy caffeine use.	Smokers With Marijuana n=18 Participants People who smoke who have heavy marijuana use	Total n=184 Participants Total of all reporting groups
Age, Continuous	40.5 years STANDARD_DEVIATION 13.4 • n=5 Participants	43.1 years STANDARD_DEVIATION 12.9 • n=7 Participants	36.4 years STANDARD_DEVIATION 14.2 • n=5 Participants	39.1 years STANDARD_DEVIATION 13.1 • n=4 Participants	46.0 years STANDARD_DEVIATION 12.9 • n=21 Participants	42.3 years STANDARD_DEVIATION 12.6 • n=8 Participants	44 years STANDARD_DEVIATION 13 • n=8 Participants
Sex: Female, Male Female	0 Participants n=5 Participants	7 Participants n=7 Participants	14 Participants n=5 Participants	0 Participants n=4 Participants	0 Participants n=21 Participants	0 Participants n=8 Participants	21 Participants n=8 Participants
Sex: Female, Male Male	47 Participants n=5 Participants	15 Participants n=7 Participants	27 Participants n=5 Participants	34 Participants n=4 Participants	22 Participants n=21 Participants	18 Participants n=8 Participants	163 Participants n=8 Participants

PRIMARY outcome

Timeframe: Primary outcome measures will be determined over approximately 3 weeks

Population: Non-smokers and smokers (with the set of different conditions: menthol, non-menthol, w/ caffeine, w/ marijuana, w/o caffeine+marijuana) who underwent PET scanning to measure the total volume of distribution Vt in the prefrontal cortex.

Vt/fp values (indicating relative densities of alpha4beta2 nicotinic acetylcholine receptors in different brain regions) in various brain regions - can also be referred to as mL/cm3.