Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
90 participants
OBSERVATIONAL
2011-11-30
2015-09-30
Brief Summary
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Detailed Description
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Traumatic brain injury (TBI) is the world leading cause of disability in children (Winslade, 1998), causing deficits in motor function, neurocognition and adaptive behaviour (Anderson, 2001). Literature shows that age at injury is inversely related to the magnitude of deficits following TBI, highlighting the vulnerability of children for the effects of TBI.
The neurocognitive consequences of paediatric TBI have primarily been characterized by impairments in speed of information processing, attentional functioning and learning (Babikian \& Asarnow, 2009; Catroppa \& Anderson, 2009), interfering with typical neurocognitive development. We aim at elucidating the effects of TBI on neurocognitive function and investigate the relations between neurocognitive deficits, academic achievement and emotional and behavioural function, in order to improve our understanding of the post-injury functioning of children that have suffered TBI.
Methods:
Patients with TBI will be compared to a control group consisting of orthopedically injured patients. Orthopaedic control (OC) groups offer a better comparison to TBI patients than typically developing children by controlling for TBI risk factors related to neurocognition (e.g. Attention Deficit Hyperactivity Disorder, socioeconomic status), hospitalisation and the type of injuries other than brain injuries.
Measures:
Child's Orientation and Amnesia Test, Attention Network Test, Probabilistic Learning Test, Child Behaviour Checklist, Strengths \& Difficulties Questionnaire, Experimental Neurocognitive Test developed at the VU University and Pupil Monitoring System.
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Patients with traumatic injuries
Children that were admitted to the hospital after traumatic injuries to body parts below the clavicles (traumatic control injury) and children that were admitted to the hospital after traumatic brain injury as diagnosed by a physician (TBI).
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* have parental written informed consent
* provide written informed consent if aged over 11 years
* are Dutch speaking
* have a clinical diagnosis of TBI (closed head injury)
* have a time post-injury that is longer than 1 month
* are aged between 6-12 years.
Trauma control patients will be included if they:
* have parental written informed consent
* provide written consent if aged over 11 years
* are Dutch speaking
* have suffered an orthopaedic injury
* have no history of TBI
* and are aged between 6-12 years.
6 Years
12 Years
ALL
No
Sponsors
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Amsterdam UMC, location VUmc
OTHER
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
OTHER
Marsh Königs
OTHER
Responsible Party
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Marsh Königs
MSc
Principal Investigators
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Jaap Oosterlaan, PhD
Role: PRINCIPAL_INVESTIGATOR
VU University of Amsterdam
Locations
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Libra rehabilitation centers Blixembosch Leijpark
Eindhoven - Tilburg, North Brabant, Netherlands
Academic Medical Center
Amsterdam, North Holland, Netherlands
VU University of Amsterdam
Amsterdam, North Holland, Netherlands
Merem revalidatiecentra de Trappenberg
Huizen, North Holland, Netherlands
Erasmus MC
Rotterdam, South Holland, Netherlands
Countries
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Other Identifiers
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NL37226.029.11
Identifier Type: -
Identifier Source: org_study_id