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The Relationship Between Serum Levels of Angiogenin, bFGF, VEGF and Ocular Involvement in Patients With Behçet's Disease

NCT ID: NCT01720628

Last Updated: 2012-11-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

86 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-11-30

Study Completion Date

2012-02-29

Brief Summary

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Objectives: Behçet's disease (BD) is a systemic vasculitis. Since vascular endothelial dysfunction plays a prominent role in the pathogenesis of the disease, we considered angiogenic cytokines as an interesting target for investigation in BD. The aim of this study was to investigate the possible role of angiogenin, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in the pathogenesis of BD.

Design and Methods: Sixty five patients with BD and 21 healthy control subjects were included in the study. Serum angiogenin, bFGF and VEGF concentrations were determined by using in vitro enzyme immunoassay (ELISA) kits according to the manufacturer's instructions.

Detailed Description

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Conditions

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Behçet's Disease

Keywords

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Angiogenin, Behçet's disease, bFGF, VEGF

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Behçet's patients

Serum levels of angiogenin, bFGF, VEGF levels in Behçet's patients with ocular involvement group, without ocular involvement group and control group

serum levels of angiogenin, bFGF, VEGF

Intervention Type OTHER

Behçet's patients

Interventions

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serum levels of angiogenin, bFGF, VEGF

Behçet's patients

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* age between 18-65
* fulfilling the international diagnostic criteria for Behçet's disease

Exclusion Criteria

* to have another systemic disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Turkish Ophthalmology Society

OTHER

Sponsor Role lead

Responsible Party

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Yeşim Gedik Oğuz

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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ali yalçındağ

Role: STUDY_DIRECTOR

* Dışkapı Yıldırım Beyazıt Training and Research Hospital, Department of Clinical Biochemistry

Locations

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Ankara University, Faculty of Medicine, Department of Ophthalmology

Ankara, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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AFV-5813

Identifier Type: -

Identifier Source: org_study_id