Web-based Insulin Titration - An Efficacy Study

NCT ID: NCT01715090

Last Updated: 2014-11-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

73 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-12-31

Study Completion Date

2014-07-31

Brief Summary

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The main objective of the study is to determine whether an intensive web-based titration system, called PANDIT (Patient Assisting Net-based Diabetes Insulin Titration), is effective in improving glycaemic control in patients with diabetes mellitus type 2 using a basal insulin, compared to standard care.

Detailed Description

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Conditions

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Diabetes Mellitus, Type 2

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Web-based insulin titration

An online web-based insulin titration algorithm to guide patients in self-titration

Group Type EXPERIMENTAL

Web-based insulin titration

Intervention Type DEVICE

Standard care

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Web-based insulin titration

Intervention Type DEVICE

Other Intervention Names

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PANDIT

Eligibility Criteria

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Inclusion Criteria

* Male or female between 18 and 80 years
* Type 2 diabetes mellitus (diagnosed clinically) for ≥ 6 months
* Once daily basal insulin therapy usage
* No restriction on HbA1c or FPG
* BMI \< 40 kg/m2
* Ability to read and understand the Dutch language
* Familiarity with the Internet and use of a mobile phone
* Ability and willingness to adhere to the protocol
* Ability and willingness to use a web-based insulin self-titration system
* Confirmed written consent

Exclusion Criteria

* Type 1 diabetes
* Use of systemic corticosteroid in the last three months
* Recurrent severe hypoglycaemia or hypoglycaemic unawareness
* Active proliferative diabetic retinopathy
* Any clinically significant disease or disorder
* Mental condition rendering the patient unable to understand the nature, scope and possible consequences of the study
* Working in night shifts
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

OTHER

Sponsor Role lead

Responsible Party

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F Holleman

MD PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Frits Holleman, MD PhD

Role: PRINCIPAL_INVESTIGATOR

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Locations

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Academic Medical Center

Amsterdam, , Netherlands

Site Status

Countries

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Netherlands

References

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Simon AC, Holleman F, Hoekstra JB, De Clercq PA, Lemkes BA, Hermanides J, Peek N. Development of a web-based decision support system for insulin self-titration. Stud Health Technol Inform. 2011;169:103-7.

Reference Type RESULT
PMID: 21893723 (View on PubMed)

Simon AC, Holleman F, Gude WT, Hoekstra JB, Peek N. Safety of a web-based insulin titration system for patients with type 2 diabetes mellitus - pilot study. Stud Health Technol Inform. 2012;180:731-5.

Reference Type RESULT
PMID: 22874288 (View on PubMed)

Gude WT, Simon AC, Peute LW, Holleman F, Hoekstra JB, Peek N, Jaspers MW. Formative usability evaluation of a web-based insulin self-titration system: preliminary results. Stud Health Technol Inform. 2012;180:1209-11.

Reference Type RESULT
PMID: 22874403 (View on PubMed)

Other Identifiers

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NL 40248.018.12

Identifier Type: -

Identifier Source: org_study_id