Piperacillin/Tazobactam for Empirical Therapy of Febrile Neutropenia
NCT ID: NCT01714570
Last Updated: 2014-04-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
123 participants
INTERVENTIONAL
2012-11-30
2014-04-30
Brief Summary
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The current study will evaluate the efficacy of piperacillin/tazobactam compared with imipenem/cilastatin for febrile neutropenia after transplantation.
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Detailed Description
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2. Randomize the febrile patients into 2 groups.
3. Therapy group receive piperacillin/tazobactam, 4.5g q6h iv. Control group receive imipenem/cilastatin, 0.5g q6h. Duration will be 5-10 days.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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piperacillin/tazobactam
Piperacillin-tazobactam combination product
4.5g q6h, 5-10 days
imipenem/cilastatin
Imipenem
0.5g q6h, 5-10 days
Interventions
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Piperacillin-tazobactam combination product
4.5g q6h, 5-10 days
Imipenem
0.5g q6h, 5-10 days
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* received Autologous or Allogeneic hematopoietic stem cell transplantation.
* ECOG score 0-1.
* ICF is available.
Exclusion Criteria
* Documented infection before neutropenia.
* Renal dysfunction.
* Suffering from central nervous system or mental disease.
13 Years
65 Years
ALL
No
Sponsors
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Chinese PLA General Hospital
OTHER
Responsible Party
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Wenrong Huang
Associate director, Hematology, Chinese PLA General hospital
Principal Investigators
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wenrong huang, Doctor
Role: PRINCIPAL_INVESTIGATOR
Employee
Locations
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Chinese PLA general hospital
Beijing, Beijing Municipality, China
Countries
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Other Identifiers
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PTZ-20120702
Identifier Type: -
Identifier Source: org_study_id
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