Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
18 participants
OBSERVATIONAL
2012-01-31
2015-05-31
Brief Summary
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These patients are often regarded as one entity in postoperative study settings. However, previous studies indicate that risk profiles, inflammatory activity, and haemodynamic capacity may differ between these groups. The first aim of this study was to evaluate postoperative ICU-requirements after open elective abdominal aortic surgery, hypothesising that AAA-patients had longer ICU-stays and needed more mechanical ventilation or acute dialysis than did patients with AOD.
The investigators see a relatively high incidence of postoperative acute kidney injury (AKI) following aortic surgery. Neutrophil Gelatinase Associated Lipocalcin (NGAL) may be useful in the early diagnosis of postopeative AKI. However, NGAL is also known as a marker of inflammatory activation. The ischaemia-reperfusion injury and subsequent inflammatory response to aortic cross clamping may per se induce a rise in NGAL despite intact renal function. Therefore NGAL may not be a reliable marker of AKI after AAS.
The second aim of this study is to describe the changes in NGAL after AAS in patients with and without postoperative dialysis-dependent AKI.
Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Aortic aneurysm patients
10 patients with a CT verified diagnosis of aortic aneurysm demanding open elective surgical correction with insertion of vascular prosthesis
No interventions assigned to this group
Aortic occlusive disease patients
10 patients with CT verified aortic occlusive disease demanding open elective surgical correction with insertion of vascular prosthesis
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* contraindications to the use of oesophagus doppler monitor, eg mycosis, perforation, stenosis.
18 Years
100 Years
ALL
No
Sponsors
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Sygehus Lillebaelt
OTHER
Responsible Party
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Helene Korvenius Nedergaard
MD
Locations
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Lillebaelt Hospital, Kolding Hospital
Kolding, , Denmark
Countries
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Other Identifiers
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S-20110154
Identifier Type: -
Identifier Source: org_study_id