Clinical Pharmacokinetics Study of ART-123 in Disseminated Intravascular Coagulation (DIC) Subjects With Renal Impairment

NCT ID: NCT01704001

Last Updated: 2017-02-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-10-31

Study Completion Date

2014-06-30

Brief Summary

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To investigate the impact of impaired renal function on the pharmacokinetics of ART-123 in patients with Disseminated Intravascular Coagulation.

To investigate the safety of ART-123 in patients with Disseminated Intravascular Coagulation.

Detailed Description

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Conditions

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Disseminated Intravascular Coagulation

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Renal impairment grade 0

Group Type EXPERIMENTAL

ART-123

Intervention Type DRUG

380 U/kg/day or 130 U/kg/day(Subjects with severe renal impairment) for 6 days

Renal impairment grade 1

Group Type EXPERIMENTAL

ART-123

Intervention Type DRUG

380 U/kg/day or 130 U/kg/day(Subjects with severe renal impairment) for 6 days

Renal impairment grade 2

Group Type EXPERIMENTAL

ART-123

Intervention Type DRUG

380 U/kg/day or 130 U/kg/day(Subjects with severe renal impairment) for 6 days

Renal impairment grade 3

Group Type EXPERIMENTAL

ART-123

Intervention Type DRUG

380 U/kg/day or 130 U/kg/day(Subjects with severe renal impairment) for 6 days

Interventions

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ART-123

380 U/kg/day or 130 U/kg/day(Subjects with severe renal impairment) for 6 days

Intervention Type DRUG

Other Intervention Names

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Recomodulin™

Eligibility Criteria

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Inclusion Criteria

* Japanese Association for Acute Medicine-defined DIC criteria score \>= 4
* Written informed consent from patient or guardian

Exclusion Criteria

* Patients showing intracranial, pulmonary, gastrointestinal hemorrhage
* Patients with a history of cerebrovascular disorders within the past 52 week
* Patients with a history of hypersensitivity to the ingredients of ART-123 preparations
* Pregnant women, nursing mothers or possibly pregnant women
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Asahi Kasei Pharma Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Ōita, , Japan

Site Status

Countries

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Japan

Other Identifiers

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ART-123 IV-2

Identifier Type: -

Identifier Source: org_study_id

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