Comparative In-Vivo Wetting Characteristics of Silicone Hydrogel Materials With Selected Lens Care Systems

NCT ID: NCT01699750

Last Updated: 2014-12-08

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

109 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-12-31

Study Completion Date

2013-11-30

Brief Summary

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The purpose of this study is to evaluate the lipid uptake, wetting characteristics, and visual performance of AIR OPTIX® AQUA and ACUVUE® OASYS® with HYDRACLEAR® contact lenses when used in conjunction with two contact lens care systems.

Detailed Description

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This study will be divided into two phases. In the Pre-Investigational Phase (Phase 1), participants will wear PureVision contact lenses for 30 days and use ReNu® Multiplus® for contact lens care. Eligible participants will continue into the Investigational Phase (Phase 2) and be randomly assigned to wear AIR OPTIX® AQUA contact lenses or ACUVUE® OASYS® with HYDRACLEAR® contact lenses for a total of two months. For contact lens care, participants will use OPTI-FREE® PUREMOIST® MPDS and BIOTRUE® for 30 days each.

Conditions

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Myopia Astigmatism Refractive Error

Keywords

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contact lenses contact lens solution myopia astigmatism

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Blinding Strategy

SINGLE

Participants

Study Groups

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Air Optix Aqua

Lotrafilcon B contact lenses with OFPM and BIOTRUE for 30 days each

Group Type EXPERIMENTAL

Lotrafilcon B contact lenses

Intervention Type DEVICE

Silicone hydrogel contact lenses, Phase 2

OPTI-FREE® PUREMOIST® MPDS

Intervention Type DEVICE

Contact lens care system, Phase 2

BIOTRUE®

Intervention Type DEVICE

Contact lens care system, Phase 2

Balafilcon A contact lenses

Intervention Type DEVICE

Silicone hydrogel contact lenses worn for 30 days, Phase 1

ReNu® Multiplus®

Intervention Type DEVICE

Contact lens care system used for 30 days, Phase 1

Acuvue Oasys

Senofilcon A contact lenses with OFPM and BIOTRUE for 30 days each

Group Type ACTIVE_COMPARATOR

Senofilcon A contact lenses

Intervention Type DEVICE

Silicone hydrogel contact lenses, Phase 2

OPTI-FREE® PUREMOIST® MPDS

Intervention Type DEVICE

Contact lens care system, Phase 2

BIOTRUE®

Intervention Type DEVICE

Contact lens care system, Phase 2

Balafilcon A contact lenses

Intervention Type DEVICE

Silicone hydrogel contact lenses worn for 30 days, Phase 1

ReNu® Multiplus®

Intervention Type DEVICE

Contact lens care system used for 30 days, Phase 1

Interventions

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Lotrafilcon B contact lenses

Silicone hydrogel contact lenses, Phase 2

Intervention Type DEVICE

Senofilcon A contact lenses

Silicone hydrogel contact lenses, Phase 2

Intervention Type DEVICE

OPTI-FREE® PUREMOIST® MPDS

Contact lens care system, Phase 2

Intervention Type DEVICE

BIOTRUE®

Contact lens care system, Phase 2

Intervention Type DEVICE

Balafilcon A contact lenses

Silicone hydrogel contact lenses worn for 30 days, Phase 1

Intervention Type DEVICE

ReNu® Multiplus®

Contact lens care system used for 30 days, Phase 1

Intervention Type DEVICE

Other Intervention Names

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AIR OPTIX® AQUA AOA ACUVUE® OASYS® with HYDRACLEAR® AVO OFPM PureVision

Eligibility Criteria

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Inclusion Criteria

* Read and understand the Participant Information Sheet;
* Read, sign, and date the Informed Consent;
* Be a current silicone hydrogel contact lens wearer using the contact lenses under a frequent replacement (bi-weekly or monthly) daily wear modality;
* Be classified as symptomatic and a depositor at the end of the replacement period according to protocol-specified criteria;
* Agree to wear study contact lenses as directed for the duration of the study and maintain the appointment schedule;
* Best corrected visual acuity of 6/9 or better in each eye;
* Normal eyes with the exception of the need for visual correction;

Exclusion Criteria

* Known sensitivity or intolerance to any of the contact lenses or contact lens care products to be used;
* Monocular vision (only one eye with functional vision or only one eye fitted with contact lenses);
* Use of systemic medication which might interfere with contact lens wear or produce dry eye side effects;
* Systemic disease which might interfere with contact lens wear or produce dry eye side effects;
* Systemic or ocular allergies which might interfere with contact lens wear;
* Ocular disease which might interfere with contact lens wear;
* Active ocular infection;
* Use of any concomitant topical ocular medications during the study period;
* Previous ocular surgery;
* Pregnant, planning to become pregnant, or lactating at the time of enrollment;
* Participation in an investigational drug or device study within 30 days of entering this study;
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Alcon Research

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jami Kern, PhD

Role: STUDY_DIRECTOR

Alcon Research

Locations

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Contact Alcon Call Center at 1-888-451-3937 for Trial Locations

Fort Worth, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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M-12-043 / ID11-59

Identifier Type: -

Identifier Source: org_study_id