Safety and Efficacy Study of JTT-851 in Patients With Type 2 Diabetes Mellitus

NCT ID: NCT01699737

Last Updated: 2013-08-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

325 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-09-30

Study Completion Date

2013-07-31

Brief Summary

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The purpose of this study is to evaluate the effect of JTT-851 on diabetes as well as to assess the safety, tolerability, and pharmacokinetics of JTT-851 in type 2 diabetic patients either treated with metformin or treatment-naïve.

Detailed Description

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This is a randomized, double-blind, double-dummy, placebo and active-controlled (glimepiride), multi-center, parallel-group study to investigate the effect of JTT-851 on HbA1c and other ancillary efficacy parameters and to assess the safety, tolerability, and pharmacokinetics of JTT-851 in inadequately-controlled treatment-naïve or metformin-treated type 2 diabetic patients.

Conditions

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Type 2 Diabetes Mellitus

Keywords

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Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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JTT-851 Dose 1

JTT-851 Tablets and Placebo comparator capsule, administered once daily for 12 weeks

Group Type EXPERIMENTAL

JTT-851

Intervention Type DRUG

Placebo for comparator

Intervention Type DRUG

JTT-851 Dose 2

JTT-851 Tablets and Placebo comparator capsule, administered once daily for 12 weeks

Group Type EXPERIMENTAL

JTT-851

Intervention Type DRUG

Placebo for comparator

Intervention Type DRUG

JTT-851 Dose 3

JTT-851 Tablets and Placebo comparator capsule, administered once daily for 12 weeks

Group Type EXPERIMENTAL

JTT-851

Intervention Type DRUG

Placebo for comparator

Intervention Type DRUG

Glimepiride Dose 1

Active Comparator Capsule and Placebo Tablets, administered once daily for 12 weeks

Group Type ACTIVE_COMPARATOR

Glimepiride

Intervention Type DRUG

Encapsulated Glimepiride tablets

Placebo for Active

Intervention Type DRUG

Placebo active & Placebo comparator

Placebo Tablets for study drug and Placebo Capsule for active comparator, administered once daily for 12 weeks

Group Type PLACEBO_COMPARATOR

Placebo for Active

Intervention Type DRUG

Placebo for comparator

Intervention Type DRUG

Interventions

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JTT-851

Intervention Type DRUG

Glimepiride

Encapsulated Glimepiride tablets

Intervention Type DRUG

Placebo for Active

Intervention Type DRUG

Placebo for comparator

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Males and females with type 2 diabetes, 18-70 years of age at Visit 1
* Managing diabetes with diet and exercise only or currently being treated with a stable dose of metformin (at least 1500 mg/day)
* Glycosylated hemoglobin at Visit 1 between 7.5% and 10.0%, if on metformin and between 7.5% and 10.9%, if without treatment
* Body mass index (BMI) ≥ 23.0 kg/m\^2 and ≤ 45.0 kg/m\^2 at Visit 1

Exclusion Criteria

* Females who are pregnant or breast-feeding
* Known medical history or presence of type 1 diabetes or acute metabolic diabetic complications, unstable or rapidly progressing retinopathy, nephropathy or neuropathy
* Acute coronary syndrome or uncontrolled hypertension
* Does not meet all diet or previous/concomitant medication restriction criteria
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Akros Pharma Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hisashi Kodama, Ph.D.

Role: STUDY_CHAIR

Akros Pharma Inc.

Locations

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Birmingham, Alabama, United States

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Dothan, Alabama, United States

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Huntsville, Alabama, United States

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Montgomery, Alabama, United States

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Muscle Shoals, Alabama, United States

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Glendale, Arizona, United States

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Tucson, Arizona, United States

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Little Rock, Arkansas, United States

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Artesia, California, United States

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Beverly Hills, California, United States

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Buena Park, California, United States

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Chino, California, United States

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Garden Grove, California, United States

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Lincoln, California, United States

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Lomita, California, United States

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Los Angeles, California, United States

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Newport Beach, California, United States

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North Hollywood, California, United States

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Paramount, California, United States

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Sacramento, California, United States

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Spring Valley, California, United States

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Walnut Creek, California, United States

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Denver, Colorado, United States

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Cooper City, Florida, United States

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Fort Lauderdale, Florida, United States

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Hialeah, Florida, United States

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Kissimee, Florida, United States

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Miami, Florida, United States

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Miramar, Florida, United States

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Ocala, Florida, United States

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Orlando, Florida, United States

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Ormond Beach, Florida, United States

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Pembroke Pines, Florida, United States

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Port Orange, Florida, United States

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Tampa, Florida, United States

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Columbus, Georgia, United States

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Marietta, Georgia, United States

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Nampa, Idaho, United States

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Chicago, Illinois, United States

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Evanston, Illinois, United States

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Indianapolis, Indiana, United States

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Wichita, Kansas, United States

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Lake Charles, Louisiana, United States

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New Orleans, Louisiana, United States

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Oxon Hill, Maryland, United States

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Olive Branch, Mississippi, United States

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Las Vegas, Nevada, United States

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Berlin, New Jersey, United States

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Mine Hill, New Jersey, United States

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Glen Falls, New York, United States

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Greensboro, North Carolina, United States

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Cincinnati, Ohio, United States

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Kettering, Ohio, United States

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Marion, Ohio, United States

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Munroe Falls, Ohio, United States

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Wadsworth, Ohio, United States

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Norman, Oklahoma, United States

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Oklahoma City, Oklahoma, United States

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Eugene, Oregon, United States

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Portland, Oregon, United States

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Lansdale, Pennsylvania, United States

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Columbia, South Carolina, United States

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Greer, South Carolina, United States

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Carrollton, Texas, United States

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Corpus Christi, Texas, United States

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Dallas, Texas, United States

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Houston, Texas, United States

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Plano, Texas, United States

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San Antonio, Texas, United States

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Sugarland, Texas, United States

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Tomball, Texas, United States

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Murray, Utah, United States

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Orem, Utah, United States

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Salt Lake City, Utah, United States

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Burke, Virginia, United States

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Manassas, Virginia, United States

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Norfolk, Virginia, United States

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Suffolk, Virginia, United States

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Madison, Wisconsin, United States

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Countries

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United States

Other Identifiers

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AT851-U-12-002

Identifier Type: -

Identifier Source: org_study_id