Bioequivalence Of Zoloft ODT To Jzoloft In Healthy Japanese Subjects

NCT ID: NCT01699724

Last Updated: 2021-01-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-09-30

Study Completion Date

2012-10-31

Brief Summary

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The purpose of this study is to assess the bioequivalence of Zoloft ODT 50 mg with and without water to Japanese commercial oral tablet of JZoloft 50 mg under fasting condition with water in Healthy Japanese Subjects

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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JZoloft

Oral tablet of sertraline hydrochloride (Japanese commercial tablet: JZoloft ® tablet) 50 mg as a single oral dose under fasted conditions

Group Type ACTIVE_COMPARATOR

JZoloft

Intervention Type DRUG

50 mg tablet on Day 1 of each period

ODT without water

sertraline ODT 50 mg without water as a single oral dose under fasted conditions

Group Type EXPERIMENTAL

sertraline ODT

Intervention Type DRUG

50 mg tablet on Day 1 of each period

ODT with water

sertraline ODT 50 mg with water as a single oral dose under fasted conditions

Group Type EXPERIMENTAL

sertraline ODT

Intervention Type DRUG

50 mg tablet on Day 1 of each period

Interventions

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JZoloft

50 mg tablet on Day 1 of each period

Intervention Type DRUG

sertraline ODT

50 mg tablet on Day 1 of each period

Intervention Type DRUG

sertraline ODT

50 mg tablet on Day 1 of each period

Intervention Type DRUG

Other Intervention Names

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sertraline hydrochloride

Eligibility Criteria

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Inclusion Criteria

* Healthy Japanese subjects between the ages of 20 and 55 years.
* Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight \>50 kg (110 lbs).

Exclusion Criteria

* Significant psychiatric disorder, recurrent episodes of severe depression, or subjects with serious suicidal risk per criteria.
* Pregnant or nursing females; females of childbearing potential who are unwilling or unable to use an acceptable method of nonhormonal contraception as outlined in this protocol from at least 14 days prior to the first dose of study medication and for 28 days after the last dose of study medication.
Minimum Eligible Age

20 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Pfizer Investigational Site

Hachioji-shi, Tokyo, Japan

Site Status

Countries

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Japan

Related Links

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Other Identifiers

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A0501098

Identifier Type: -

Identifier Source: org_study_id

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