Pressure Dependent Tracheal Obstruction in Copd Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

104 participants

Study Classification

OBSERVATIONAL

Study Start Date

2004-08-31

Study Completion Date

2011-08-31

Brief Summary

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Background. Do pressure dependent tracheal obstructions (PDTO) often seen during bronchoscopy in COPD patients affect pulmonary function tests and breathing symptoms? Method. Model study. A garden hose was compressed from one side to simulate the posterior wall of the trachea bulging into the lumen. For two obstruction lengths - 3 cm and 12 cm, the hose was increasingly compressed in eight steps. Resistance was measured at each step for airflows 1 l/s through 9 l/s, and digital photos of the luminal area were taken which were used by a computer to estimate the cross sectional area reduction and the corresponding distance between the bulging (posterior)and the opposite (anterior) wall (AP-distance).

Patient study. 104 stable COPD patients studied by pulmonary function tests and bronchoscopy. The tracheal obstruction was observed during forced expiration and cough, and the cross sectional area reduction was estimated using the results from the model study.

Detailed Description

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Conditions

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Tracheobronchomalacia

Keywords

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copd airway obstruction Tracheobronchomalacia

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* copd

Exclusion Criteria

* clinical evidence of malignant disease
* not able to be subjected to bronchoscopy

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ivar Ellingsen, Dr med

Role: PRINCIPAL_INVESTIGATOR

LHL Helse

Locations

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Glittreklinikken

Hakadal, Akershus, Norway

Site Status

Countries

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Norway

Other Identifiers

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s-04058c

Identifier Type: REGISTRY

Identifier Source: secondary_id

GK-18

Identifier Type: -

Identifier Source: org_study_id