Study of Yili Lactoferrin ShuHua Milk in the Improvement of Human Immunization

NCT ID: NCT01677702

Last Updated: 2012-10-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

240 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-03-31

Study Completion Date

2011-10-31

Brief Summary

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The purpose of this study is to determine whether Yili Lactoferrin ShuHua Milk are effective in reducing the occurrence of flu symptoms.

Detailed Description

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Conditions

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Immunization Human Influenza Common Cold

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Yili Lactoferrin ShuHua Milk (lactoferrin 5mg/100ml)

Total 250mL milk (with lactoferrin 5mg/100ml) will be taken once per day at 10am daily during the 84 days intervention.

Group Type ACTIVE_COMPARATOR

Yili Lactoferrin ShuHua Milk (Lactoferrin 5mg/100ml)

Intervention Type DIETARY_SUPPLEMENT

Total 250mL milk (with lactoferrin 5mg/100ml) will be taken once per day at 10am daily during the 84 days intervention.

Yili Lactoferrin ShuHua Milk (lactoferrin 10mg/100ml)

Total 250mL milk (with lactoferrin 10mg/100ml) will be taken once per day at 10am daily during the 84 days intervention.

Group Type ACTIVE_COMPARATOR

Yili Lactoferrin ShuHua Milk (Lactoferrin 10mg/100ml)

Intervention Type DIETARY_SUPPLEMENT

Total 250mL milk (with lactoferrin 10mg/100ml) will be taken once per day at 10am daily during the 84 days intervention.

Recombined low-protein milk

Total 250mL placebo milk will be taken once per day at 10am daily during the 84 days intervention.

Group Type PLACEBO_COMPARATOR

Recombined low protein milk

Intervention Type DIETARY_SUPPLEMENT

Total 250ml of placebo milk will be taken once a day at 10am daily during the 84 day intervention.

Interventions

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Yili Lactoferrin ShuHua Milk (Lactoferrin 5mg/100ml)

Total 250mL milk (with lactoferrin 5mg/100ml) will be taken once per day at 10am daily during the 84 days intervention.

Intervention Type DIETARY_SUPPLEMENT

Yili Lactoferrin ShuHua Milk (Lactoferrin 10mg/100ml)

Total 250mL milk (with lactoferrin 10mg/100ml) will be taken once per day at 10am daily during the 84 days intervention.

Intervention Type DIETARY_SUPPLEMENT

Recombined low protein milk

Total 250ml of placebo milk will be taken once a day at 10am daily during the 84 day intervention.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Age 6 to 12 years, catch cold for 4 to 6 times in last year;
* Age 35 to 45 years, catch cold for 4 to 6 times in recent 3 month;
* Age 60 to 75 years, catch cold for 4 to 6 times in last year;
* BMI 18.5to 29.9kg/m2;
* Able to understand the nature and purpose of the study including potential risks and side effects

Exclusion Criteria

* Recent (within 6 months of screening) been vaccinated influenza vaccine, or recent (within 15 days of screening) been vaccinated ther vaccines;
* Suffering from rhinitis chronic, laryngitis, labored breathing that similar to flu symptoms. Such as chronic allergic rhinitis, asthma, COPD;
* Long-term use of any prescription or OTC medication that inhibit or prevent flu symptoms, including but not limited to, antihistamine, pectoral, high doses of vitamin C;
* Recent use (within 3 months of screening) of any prescription or OTC medication that significantly affects immune response, such as antibiotic;
* Known allergies to dairy and any substance in the study product;
* History of alcohol, drug, or medication abuse
* Pregnant or breastfeeding women
* Recent daily use (within 3 months of screening) of any probiotics, clabber or yogurt;
* Any comorbidity that could, in the opinion of the investigator, preclude the subject's ability to successfully and safely complete the study or that may confound study outcomes
Minimum Eligible Age

6 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Inner Mongolia Yili Industrial Group Co., Ltd

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ying An, Ph.D

Role: STUDY_DIRECTOR

Inner Mongolia Hilo Industrial Group Co., Ltd

Donglian Cai

Role: PRINCIPAL_INVESTIGATOR

Changhai Hospital of Shanghai, Nutriology Dept.

Yeqing Shi

Role: PRINCIPAL_INVESTIGATOR

Changhai Hospital of Shanghai, Rheumatology Dept.

Locations

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NanMoFang Community Health Service Center

Chao Yang District, Beijing Municipality, China

Site Status

JuQuan Community Health Service Center

GuCun, Baoshan District,, Shanghai Municipality, China

Site Status

Countries

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China

Other Identifiers

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YL/CL-002

Identifier Type: -

Identifier Source: org_study_id