Study Evaluating Changes in Total Drug Load and Seizure Frequency Using Vimpat® (Lacosamide) in Combination Therapy

NCT ID: NCT01673282

Last Updated: 2016-11-15

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

315 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-07-31

Study Completion Date

2015-07-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This observational study aims to investigate how VIMPAT® is used as adjunctive therapy in clinical practice and will also evaluate the subsequent change in the drug load of patients after addition of VIMPAT® to their treatment regimen.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Focal Epilepsy With and Without Secondary Generalization

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

Lacosamide Vimpat Focal Epilepsy Drug Load AED SP1065

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Vimpat + Na Channel Blocking AED

Patients prescribed adjunctive lacosamide (LCM) added to one or more baseline Anti-Epileptic Drugs (AEDs) to include at least 1 sodium channel blocking AED.

Lacosamide

Intervention Type DRUG

Route of Administration: oral/subcutaneous Form and Dosage: Tablet (50 mg/100 mg/150 mg, 200 mg); Syrup (10 mg/ml); Solution for infusion (10 mg/ml).

Vimpat + Non-Na Channel Blocking AED

Patients prescribed adjunctive lacosamide (LCM) added to one or more baseline Anti-Epileptic Drugs (AEDs), none of which is a sodium channel blocking AED.

Lacosamide

Intervention Type DRUG

Route of Administration: oral/subcutaneous Form and Dosage: Tablet (50 mg/100 mg/150 mg, 200 mg); Syrup (10 mg/ml); Solution for infusion (10 mg/ml).

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Lacosamide

Route of Administration: oral/subcutaneous Form and Dosage: Tablet (50 mg/100 mg/150 mg, 200 mg); Syrup (10 mg/ml); Solution for infusion (10 mg/ml).

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Vimpat LCM

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* The patient has not received Vimpat® more than 7 days prior to start of Non-Interventional Study (NIS)
* The patient must have a diagnosis of epilepsy with partial-onset seizures with or without secondary generalization
* Based on the physician's clinical judgment, it is in the patient's best interest to be prescribed adjunctive Vimpat® (ie, the decision to prescribe Vimpat® is made by the physician)
* Patient must be at least 18 years of age
* The patient must have had at least one seizure within the last 3 months prior to enrolment
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

UCB Pharma GmbH

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

UCB Clinical Trial Call Center

Role: STUDY_DIRECTOR

UCB Pharma

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

60

Innsbruck, , Austria

Site Status

61

Mauer bei Amstetten, , Austria

Site Status

63

Ried, , Austria

Site Status

18

Berlin, , Germany

Site Status

34

Berlin, , Germany

Site Status

43

Berlin, , Germany

Site Status

66

Berlin, , Germany

Site Status

23

Bonn, , Germany

Site Status

28

Cologne, , Germany

Site Status

40

Cologne, , Germany

Site Status

25

Dortmund, , Germany

Site Status

35

Düsseldorf, , Germany

Site Status

48

Erbach im Odenwald, , Germany

Site Status

59

Erlangen, , Germany

Site Status

30

Essen, , Germany

Site Status

47

Giessen, , Germany

Site Status

29

Göttingen, , Germany

Site Status

37

Göttingen, , Germany

Site Status

05

Haag, , Germany

Site Status

12

Halle, , Germany

Site Status

19

Halle, , Germany

Site Status

39

Heidenheim, , Germany

Site Status

54

Ibbenbueren, , Germany

Site Status

27

Jena, , Germany

Site Status

04

Jülich, , Germany

Site Status

13

Kehl-Kork, , Germany

Site Status

36

Kiel, , Germany

Site Status

38

Leipzig, , Germany

Site Status

52

Magdeburg, , Germany

Site Status

67

Mainz, , Germany

Site Status

49

Mittweida, , Germany

Site Status

01

München, , Germany

Site Status

08

Oranienburg, , Germany

Site Status

17

Osnabrück, , Germany

Site Status

14

Radeberg, , Germany

Site Status

15

Rüsselsheim am Main, , Germany

Site Status

16

Senftenberg, , Germany

Site Status

41

Stuttgart, , Germany

Site Status

09

Troisdorf, , Germany

Site Status

22

Tübingen, , Germany

Site Status

20

Ulm, , Germany

Site Status

07

Westerstede, , Germany

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Austria Germany

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

SP1065

Identifier Type: -

Identifier Source: org_study_id