Efficacy and Safety of Diclofenac Potassium 25 mg Tablet Taken Three Times Daily in Subjects With Acute Joint Pain

NCT ID: NCT01666197

Last Updated: 2014-04-17

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-08-31

Study Completion Date

2013-01-31

Brief Summary

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The purpose of this study is to evaluate the efficacy of diclofenac potassium 25 mg tablet compared with placebo taken three times a day in subjects with acute ankle sprains under 'in-use' conditions, in particular with regard to pain relief.

Detailed Description

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Conditions

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Ankle Sprain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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diclofenac potassium 25 mg tablet

Group Type EXPERIMENTAL

diclofenac potassium 25 mg tablet

Intervention Type DRUG

diclofenac potassium 25 mg tablet

placebo

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DRUG

placebo

Interventions

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diclofenac potassium 25 mg tablet

diclofenac potassium 25 mg tablet

Intervention Type DRUG

placebo

placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or female aged 18 years and over.
* Acute sprain of the lateral ankle, Grade I-II, meeting baseline pain intensity level.
* Injury within past 12 hours.

Exclusion Criteria

* Pain medication was taken within the 6 hours that precede randomization.
* During the past 3 months: Grade I-III sprain of the same ankle.
* During the past 6 months: Grade II-III sprain, any other significant injury (such as fracture or torn ligament), or surgery (except for skin or nails) of the same ankle or foot.
* Pain or instability in the same ankle attributable to previous ankle sprain or any other trauma.
* Ankle sprain attributable to a known disease affecting the ligaments, such as ligament hyperlaxity due to connective tissue disease (e.g., Marfan's syndrome, Down's syndrome, Ehlers-Danlos syndrome).
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Novartis

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Investigator

Brühl, , Germany

Site Status

Investigator

Cologne, , Germany

Site Status

Investigator

Essen, , Germany

Site Status

Investigator

Gilching, , Germany

Site Status

Countries

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Germany

Other Identifiers

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853-P-401

Identifier Type: -

Identifier Source: org_study_id

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