Real-life Effectiveness of the Kaletra Adherence Support Assistance (KASA) Program

NCT ID: NCT01662336

Last Updated: 2018-01-29

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

173 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-06-30

Study Completion Date

2016-06-30

Brief Summary

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The overall purpose of the study was to describe the real-life adherence, effectiveness and safety of the Kaletra Adherence Support Assistance (KASA) Program in human immunodeficiency virus (HIV)-positive patients who were receiving treatment with lopinavir / ritonavir (LPV/r; Kaletra®) in Canada.

Detailed Description

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The Kaletra Adherence Support Assistance (KASA) Program is a customized support network that has been offered to patients treated with lopinavir / ritonavir (LPV/r; Kaletra®). KASA offers individual counseling with an HIV experienced nurse who assists patients with various aspects of their therapy including life-style changes, emotional stress, and adverse events. Patients enrolled in KASA may also have access to various healthcare professionals (dietician, social worker, psychologist, etc.) or may be offered other types of support (transportation, exercise, etc.), which may help improve their quality of life as well as adherence or compliance while taking LPV/r.

This was a 12-month, multi-center, Canadian Post Marketing Observational Study utilizing a prospective single cohort design. All treatments including participation in the KASA program were according to the decision of the treating physician and the patients and were not affected in any way by their decision to participate in the study. Follow-up was for 12 months at an interval of every six months.

Conditions

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Human Immunodeficiency Virus Infection

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Lopinavir/Ritonavir + KASA

Patients were treated according to the standard of care provided by their respective study sites. Treatments with LPV/r and participation in the KASA program were according to the decision of the treating physician and the participant, and were not affected in any way by their decision to participate in the study.

Lopinavir / ritonavir

Intervention Type DRUG

Prescribed according to the product monograph and physician's discretion.

Kaletra Adherence Support Assistance Program

Intervention Type BEHAVIORAL

A customized support network for patients treated with lopinavir / ritonavir that offers individual counseling with an HIV experienced nurse who assists patients with various aspects of their therapy including life-style changes, emotional stress, and adverse events, and may provide access to various healthcare professionals or may offer other types of support such as transportation, exercise, etc.

Interventions

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Lopinavir / ritonavir

Prescribed according to the product monograph and physician's discretion.

Intervention Type DRUG

Kaletra Adherence Support Assistance Program

A customized support network for patients treated with lopinavir / ritonavir that offers individual counseling with an HIV experienced nurse who assists patients with various aspects of their therapy including life-style changes, emotional stress, and adverse events, and may provide access to various healthcare professionals or may offer other types of support such as transportation, exercise, etc.

Intervention Type BEHAVIORAL

Other Intervention Names

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Kaletra® LPV/r KASA

Eligibility Criteria

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Inclusion Criteria

* Subject is HIV-positive
* On treatment with LPV/r or currently initiated on treatment with LPV/r.
* Has provided written informed consent allowing the use of their data for the study and providing permission for contact by the study personnel.
* Willing to be enrolled in the Kaletra Adherence Support Assistance (KASA) program.
* Prescribed LPV/r as part of his/her treatment by the treating physician.

Exclusion Criteria

* Not willing to sign an informed consent.
* In the opinion of the treating physician is unlikely to be available for the 12-month follow-up duration of the study.
* Is currently participating in a clinical trial of an investigational product.
* Not willing to participate in the KASA program.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AbbVie (prior sponsor, Abbott)

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Christina Pelizon, MD

Role: STUDY_DIRECTOR

AbbVie Corporation

Related Links

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Other Identifiers

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P13-566

Identifier Type: -

Identifier Source: org_study_id

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