Prospective Study of Motion Preservation Evaluation Below Fusions of the Spine in Adolescent Idiopathic Scoliosis

NCT ID: NCT01661998

Last Updated: 2023-11-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

273 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-06-30

Study Completion Date

2019-12-31

Brief Summary

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The purpose of this study is to evaluate the relationship of A) The distal fusion level B) The total length of fusion and the post-operative range of motion in the unfused vertebral segments below the fusion in patients with Adolescent Idiopathic Scoliosis.

Detailed Description

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The motion behavior in the unfused segments of the spine following instrumentation is poorly understood and the implications of hyper or hypo-mobility have not been clearly defined. The purpose of this study is to evaluate the relationship of A) The distal fusion level B) The total length of fusion and the post-operative range of motion in the unfused vertebral segments below the fusion in patients with Adolescent Idiopathic Scoliosis to answer the following specific clinical questions:

1. Further elucidate the motion behavior of the distal unfused spinal segments, specifically:

1. Does motion differ at various post-operative time points (2 year post-op patients versus 5 or 10 year post-op patients)?
2. Can predictive factors be identified with post-operative altered motion?
2. Further elucidate the relationship of the motion in the unfused spinal segments to the lowest instrumented vertebrae.
3. Determine the relationship of the total length of fusion to the motion in the unfused spinal segments (i.e. compare unfused motion in the distal unfused segments in Lenke 5/6 patients fused selectively (ThL/L only) versus nonselectively (TH and ThL/L)).
4. Determine the relationship between clinical examinations (i.e. reports of pain or functional limitations) and patient reported outcomes (Health Related Quality of Life Outcome Tools) to motion in the distal unfused segments.

Conditions

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Adolescent Idiopathic Scoliosis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Harms Study Group

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patient age \< 21 years
* Male or female
* Diagnosis of Adolescent Idiopathic Scoliosis
* Any Lenke Classification type
* Underwent surgical correction of the spinal deformity with a fusion
* Are due for their 10 year post-operative visit

Exclusion Criteria

* Neuromuscular co-morbidity
Minimum Eligible Age

8 Years

Maximum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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DePuy Spine

INDUSTRY

Sponsor Role collaborator

Setting Scoliosis Straight Foundation

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Peter Newton, MD

Role: STUDY_DIRECTOR

Rady Children's Hospital San Deigo

Locations

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Rady Children's Hospital

San Diego, California, United States

Site Status

Scoliosis Associates & NYU Hospital for Joint Diseases

New York, New York, United States

Site Status

Shriners Hospital for Children

Philadelphia, Pennsylvania, United States

Site Status

Countries

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United States

Related Links

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http://hsg.settingscoliosisstraight.org/current-hsg-research/

Setting Scoliosis Straight Website - highlighting the research of the Harms Study Group

Other Identifiers

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2009HSGF05

Identifier Type: -

Identifier Source: org_study_id