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The Effect of Humidification on Mucus Rheology

NCT ID: NCT01661374

Last Updated: 2014-12-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

18 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-07-31

Study Completion Date

2014-04-30

Brief Summary

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In this study the investigators will collect mucus from mechanical ventilated patients and patients with COPD to study the effect of temperature and humidity, on the biophysical properties of the airway mucus. It is hypothesised that changes in inspired gas temperature and humidity (over time) may affect the biophysical properties of the airway mucus and reduce the airway's ability to clear mucus, resulting in deleterious clinical affects.

Detailed Description

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Expectorated sputum samples are collected and used to measure the biophysical properties of mucus secretions. The samples are later exposed to different temperatures and humidity levels during bench experiments.

Conditions

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Chronic Obstructive Pulmonary Disease(COPD)

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Mechanically Ventilated

No interventions assigned to this group

Chronic obstructive pulmonary disease (COPD).

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

Any Subject Mechanically Ventilated and producing sputum.

Exclusion

* None

COPD Group


* 40 to 90 years of age suffering from COPD
* History of mucus production

Exclusion Criteria

* None
Minimum Eligible Age

40 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fisher and Paykel Healthcare

INDUSTRY

Sponsor Role collaborator

Virginia Commonwealth University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bruce K Rubin, MEngr, MD, MBA, FRCPC

Role: PRINCIPAL_INVESTIGATOR

Virginia Commonwealth University School of Medicine

Locations

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Virginia Commonwealth University

Richmond, Virginia, United States

Site Status

Countries

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United States

Other Identifiers

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HM14433

Identifier Type: -

Identifier Source: org_study_id