Nicotine Patch Safety Study

NCT ID: NCT01655082

Last Updated: 2012-12-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

160 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-08-31

Study Completion Date

2012-10-31

Brief Summary

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The purpose of this study is to evaluate the safety profile of a repeated application of a new transdermal patch compared to a reference product during 3 weeks, in a large population.

Detailed Description

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Conditions

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Smokers

Keywords

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Smoking cessation Nicotine Tobacco Use Disorder Central Nervous System Agents

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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V0116

One patch per day (during 24 hours) for 21 days

Group Type EXPERIMENTAL

V0116 transdermal patch

Intervention Type DRUG

One patch per day (during 24 hours) for 21 days

Reference

One patch per day (during 24 hours) for 21 days

Group Type ACTIVE_COMPARATOR

Nicotine transdermal patch

Intervention Type DRUG

One patch per day (during 24 hours) for 21 days

Interventions

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V0116 transdermal patch

One patch per day (during 24 hours) for 21 days

Intervention Type DRUG

Nicotine transdermal patch

One patch per day (during 24 hours) for 21 days

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or female aged more than 18 years
* Regular smoker motivated to stop tobacco consumption
* Current smoker of \> or = 20 cigarettes/day and \< or = 25 cigarettes/day or Fagerström score \> or = 5 (for smokers between 10 to 20 cigarettes/day)

Exclusion Criteria

* Any visible skin disorder, abnormal skin pigmentation or other dermatologic disease which, in the opinion of the investigator would interfere with the assessment of the different parameters
* Current or past serious chronic cardiovascular, renal, hepatic, gastrointestinal (including duodenal or gastric ulcer), endocrine, hematological, neuropsychiatric, immunosuppressive condition or allergic disease, myopathies, epileptic seizures, bleeding tendency, cancer
* History of angina pectoris, myocardial infarction or stroke in the previous 3 months, coronary artery vasospasm, cardiac arrhythmia, acute stroke
* Clinically relevant abnormal findings on the physical examination (e.g large scars on the application zone)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pierre Fabre Medicament

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Gières, , France

Site Status

Pierre-Bénite, , France

Site Status

Rennes, , France

Site Status

Rueil-Malmaison, , France

Site Status

Countries

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France

Other Identifiers

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2011-005911-94

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

V00116 TD 2 02

Identifier Type: -

Identifier Source: org_study_id