Effectiveness Of Osteopathic Manipulative Treatment In NICU: A Multicenter Clinical Trial

NCT ID: NCT01645137

Last Updated: 2014-04-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

690 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-07-31

Study Completion Date

2013-10-31

Brief Summary

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The use of complementary and alternative medicine in neonatal ward has been steadily rising during the last decade. This integrated medicine approach has been shown to be helpful to improve neonatal health care. Osteopathic manipulative treatment (OMT) has been applied to premature infants to reduce the length of stay and to cope with clinical complications. Results from previous studies documented the positive association between OMT and shorter period of hospitalisation as well as improvement of clinical conditions. The aim of this nationwide multicenter study is to demonstrate the effect of OMT on length of stay (LOS) in premature infants across 3 neonatal intensive care units (NICU).

Detailed Description

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Conditions

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Prematurity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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OMT

patients under usual medical care plus osteopathic treatment

Group Type EXPERIMENTAL

osteopathic manipulative treatment

Intervention Type OTHER

Patients from this group received osteopathic treatments twice a week for the entire length of stay in the unit.

control

patients under usual medical care

Group Type OTHER

Usual care

Intervention Type OTHER

Patients from control group received standard care plus osteopathic evaluation only, according to the same schedule as the study group.

Interventions

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osteopathic manipulative treatment

Patients from this group received osteopathic treatments twice a week for the entire length of stay in the unit.

Intervention Type OTHER

Usual care

Patients from control group received standard care plus osteopathic evaluation only, according to the same schedule as the study group.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* preterm infants born at age between 29 and 37 weeks
* osteopathic treatment performed \< 14 days after birth
* preterms born in the same hospital

Exclusion Criteria

* Gestational age \< 29 weeks
* Gestational age \> 37 weeks
* First OMT performed after 14 days from birth
* genetic disorders
* congenital disorders
* cardiovascular abnormalities
* proven or suspected necrotized enterocolitis with or without gastrointestinal perforation
* proven or suspected abdominal obstruction
* pre/post surgery patients
* pneumoperitoneum
* atelectasis
* Newborn from an HIV seropositive/drug addicted mother
* respiratory disorders
* transferred to/from other hospital
* admitted for preterminal comfort care (defined as neither intubation nor cardio-respiratory resuscitation)
Minimum Eligible Age

29 Weeks

Maximum Eligible Age

37 Weeks

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Italian Academy of Traditional Osteopathy - AIOT

OTHER

Sponsor Role collaborator

European Institute for Evidence Based Osteopathic Medicine

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Monza Hospital

Monza, Lombardy, Italy

Site Status

Macerata Hospital

Macerata, The Marches, Italy

Site Status

Pescara hospital

Pescara, , Italy

Site Status

Countries

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Italy

References

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Cerritelli F, Pizzolorusso G, Renzetti C, Cozzolino V, D'Orazio M, Lupacchini M, Marinelli B, Accorsi A, Lucci C, Lancellotti J, Ballabio S, Castelli C, Molteni D, Besana R, Tubaldi L, Perri FP, Fusilli P, D'Incecco C, Barlafante G. A multicenter, randomized, controlled trial of osteopathic manipulative treatment on preterms. PLoS One. 2015 May 14;10(5):e0127370. doi: 10.1371/journal.pone.0127370. eCollection 2015.

Reference Type DERIVED
PMID: 25974071 (View on PubMed)

Cerritelli F, Pizzolorusso G, Renzetti C, D'Incecco C, Fusilli P, Perri PF, Tubaldi L, Barlafante G. Effectiveness of osteopathic manipulative treatment in neonatal intensive care units: protocol for a multicentre randomised clinical trial. BMJ Open. 2013 Feb 20;3(2):e002187. doi: 10.1136/bmjopen-2012-002187. Print 2013.

Reference Type DERIVED
PMID: 23430598 (View on PubMed)

Related Links

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Other Identifiers

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Multi-NE-O

Identifier Type: -

Identifier Source: org_study_id

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