Study Results
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View full resultsBasic Information
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COMPLETED
NA
169 participants
INTERVENTIONAL
2013-01-31
2016-06-30
Brief Summary
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Detailed Description
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Parkinson's disease (PD) is the second most common neurodegenerative disease, affecting over one million Americans. The cardinal clinical manifestations of PD are motoric, which limit functional mobility leading to difficulty working, caring for family members, managing a household, and overall decreased independence and quality of life (QOL). A wealth of growing data indicates tremendous benefits of exercise for patients with PD. Not only have exercise programs been shown to improve motor function and reduce the risk of falls, but also improve overall QOL and possibly the very course of disease pathology. However, programs that involve supervision in the home of people with PD are expensive to roll out widely, and programs that involve people with PD traveling to a central site not only result in non-compliance over time because of difficulty getting to the site, but also rule out the involvement of a large number of people with PD who simply live too far from larger centers where such programs are typically established.
Objective:
The investigators hypothesize that a one-year in-home exercise program, centered around remote, real-time instruction and supervision, will reduce the rate of falls and improve strength and QOL in patients with PD.
Methods:
The proposed study is a randomized controlled trial of a structured exercise program, evaluating effects on fall rate, physical functioning, and QOL. Community-dwelling people with PD will be randomized either to a group who receives structured and remote exercise instruction and supervision in real-time or a group who is taught a lifestyle exercise program. Subjects will be male and female Veterans with a physician diagnosis of idiopathic, typical PD, with at least 2 of 3 cardinal signs of PD, and response to dopaminergic medication. The interventions will last one year.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
SINGLE
Study Groups
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Structured exercise
Structured exercise instruction by smartphone
Structured exercise
Structured exercise includes stretching, strengthening, and balance exercises.
lifestyle exercise
Lifestyle exercise program taught via smartphone
Lifestyle exercise
Subjects will be taught lifestyle exercises and advised about mobility strategies
Interventions
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Structured exercise
Structured exercise includes stretching, strengthening, and balance exercises.
Lifestyle exercise
Subjects will be taught lifestyle exercises and advised about mobility strategies
Eligibility Criteria
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Inclusion Criteria
* At least 2 of 3 cardinal signs of PD
* Response to dopaminergic medication
Exclusion Criteria
* History of myocardial infarction within 6 months
* History of ventricular dysrhythmia requiring current therapy
40 Years
ALL
No
Sponsors
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VA Office of Research and Development
FED
Responsible Party
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Principal Investigators
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David W Sparrow, DSc
Role: PRINCIPAL_INVESTIGATOR
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Locations
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VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Boston, Massachusetts, United States
Countries
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Other Identifiers
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IIR 11-342
Identifier Type: -
Identifier Source: org_study_id
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