A Comparison Between Paclitaxel-eluting Balloon in Combination With BMS Implantation vs Conventional Balloon and DES Implantation

NCT ID: NCT01637896

Last Updated: 2012-07-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE4

Total Enrollment

125 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-06-30

Study Completion Date

2012-07-31

Brief Summary

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The purpose of this study is to evaluate the efficacy of predilation with paclitaxel-eluting balloon and bare metal stent implantation VS conventional balloon and drug-eluting stent implantation in terms of restenosis

Detailed Description

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Conditions

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Myocardial Ischemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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DEB+BMS

drug-eluting balloon predilation and bare metal stent implantation

Group Type EXPERIMENTAL

DEB+BMS

Intervention Type DEVICE

drug-eluting balloon predilation and bare metal stent implantation

POBA+DES

conventional balloon predilation and drug-eluting stent implantation

Group Type ACTIVE_COMPARATOR

POBA+DES

Intervention Type DEVICE

conventional balloon predilation and drug-eluting stent implantation

Interventions

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DEB+BMS

drug-eluting balloon predilation and bare metal stent implantation

Intervention Type DEVICE

POBA+DES

conventional balloon predilation and drug-eluting stent implantation

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* age\> 18 years
* angina or stress test positive for ischemia
* de novo coronary stenosis\>50%

Exclusion Criteria

* recent myocardial infarction (\<72h)
* severe chronic kidney disease
* allergy to Paclitaxel
* contraindication for combined antiplatelet treatment
* life expectancy \<1 year
* hypersensitivity or contraindication to one of the study drugs
* lack of consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Leonardo Bolognese, MD

OTHER

Sponsor Role lead

Responsible Party

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Leonardo Bolognese, MD

Director

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Leonardo Bolognese, MD

Role: PRINCIPAL_INVESTIGATOR

San Donato Hospital

Locations

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Cardiovascular Department, Ospedale S.Donato

Arezzo, AR, Italy

Site Status

Countries

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Italy

Other Identifiers

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Arezzo000

Identifier Type: -

Identifier Source: org_study_id